Protein Info for HER17_RS14350 in Pectobacterium carotovorum WPP14

Annotation: beta-glucoside-specific PTS transporter subunit IIABC

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 621 transmembrane" amino acids 108 to 136 (29 residues), see Phobius details amino acids 153 to 172 (20 residues), see Phobius details amino acids 178 to 196 (19 residues), see Phobius details amino acids 213 to 231 (19 residues), see Phobius details amino acids 244 to 269 (26 residues), see Phobius details amino acids 281 to 305 (25 residues), see Phobius details amino acids 327 to 348 (22 residues), see Phobius details amino acids 359 to 378 (20 residues), see Phobius details amino acids 386 to 410 (25 residues), see Phobius details amino acids 430 to 452 (23 residues), see Phobius details TIGR01995: PTS system, beta-glucoside-specific IIABC component" amino acids 13 to 605 (593 residues), 652.7 bits, see alignment E=5.7e-200 PF00367: PTS_EIIB" amino acids 18 to 51 (34 residues), 51.6 bits, see alignment (E = 7.6e-18) PF02378: PTS_EIIC" amino acids 116 to 385 (270 residues), 104.3 bits, see alignment E=1e-33 PF00358: PTS_EIIA_1" amino acids 472 to 596 (125 residues), 161.4 bits, see alignment E=1.3e-51 TIGR00830: PTS system, glucose subfamily, IIA component" amino acids 474 to 593 (120 residues), 142.3 bits, see alignment E=7.4e-46

Best Hits

KEGG orthology group: K02755, PTS system, beta-glucosides-specific IIA component [EC: 2.7.1.69] K02756, PTS system, beta-glucosides-specific IIB component [EC: 2.7.1.69] K02757, PTS system, beta-glucosides-specific IIC component (inferred from 94% identity to pct:PC1_1349)

Predicted SEED Role

"PTS system, beta-glucoside-specific IIB component (EC 2.7.1.69) / PTS system, beta-glucoside-specific IIC component / PTS system, beta-glucoside-specific IIA component" in subsystem Beta-Glucoside Metabolism (EC 2.7.1.69)

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 2.7.1.69

Use Curated BLAST to search for 2.7.1.69

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (621 amino acids)

>HER17_RS14350 beta-glucoside-specific PTS transporter subunit IIABC (Pectobacterium carotovorum WPP14)
MSHTAADNNATAYTTTAEKIITLVGGIDNIEHIEHCSTRLRLSLYDNSQVNQNELEKVPG
VLGVRVNVQCQVIIGSEVMQVYEAVQNLAAGRKKTDRAVPAKTNRTAFVIDFIISVFQPL
VPAIAGGGVLKSLLLLLDLLGWLTKDSSTYKVLDNIGSAPLYFLPILVGITTAMKLKVNV
LVAVSAVSVMVLPAMSKQLADGAEFLSFDLKNVAYASQVFPAILCVIFYAQTEKLFNRYS
PSSLRIFLSPMLSLLVTVPVTLLVLGPLGYELGAGLASVILWLYSKLGFVATGLLAAALP
FMVASGMHKPMLPYAVSSMSQFGKEMLYLPASLAHNIAESGACMAIALKSKDKTLKSTAI
SAGISALFGITEPALYGITLLNKKALYSVIAGSLVGGAFIGWMAIEAFALVGPGLASISM
FISPENSWNIVYAIAGAALSFVIAFLSALFLWREEKPVVTVEESHHAITECQFTSPIEGK
VIPLDNVNDEIFSKRIMGDGIAIIPEKGVLYAPANGTIENVFETGHAVSMLTDSGAELIF
HIGIDTIKLNGQGFQPKVTAGQQVNTGDILVEFDLDSLIAAGYDPVVMMVITNSERFRVI
PEATDVVIHPHTTIMTLKESV