Protein Info for HER17_RS14165 in Pectobacterium carotovorum WPP14

Annotation: TlpA family protein disulfide reductase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 165 signal peptide" amino acids 1 to 22 (22 residues), see Phobius details PF08534: Redoxin" amino acids 28 to 153 (126 residues), 83.9 bits, see alignment E=2.7e-27 PF00578: AhpC-TSA" amino acids 28 to 142 (115 residues), 69.1 bits, see alignment E=8.9e-23 PF13098: Thioredoxin_2" amino acids 51 to 157 (107 residues), 30 bits, see alignment E=1.4e-10 PF13905: Thioredoxin_8" amino acids 52 to 141 (90 residues), 46.6 bits, see alignment E=8.8e-16

Best Hits

Swiss-Prot: 35% identical to RESA_BACC1: Thiol-disulfide oxidoreductase ResA (resA) from Bacillus cereus (strain ATCC 10987 / NRS 248)

KEGG orthology group: None (inferred from 94% identity to pwa:Pecwa_1789)

Predicted SEED Role

"Possible periplasmic thiredoxin"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (165 amino acids)

>HER17_RS14165 TlpA family protein disulfide reductase (Pectobacterium carotovorum WPP14)
MKWRNAITALCLLGAAALSGCKEEQVSVGAQAPALAAYDLSGQQVDLSRWQGKSVYLNFW
SSGCGGCMIEMGALEKLSQEYGDKVVVVAVNTDPDGVDVTSMLVHHKVTYPVVRDQLGIT
KERYQVSGTPTSFIIDANGKVIDQHQGARDEAQLTELFQKLASRT