Protein Info for HER17_RS14145 in Pectobacterium carotovorum WPP14

Annotation: glutamate/aspartate:proton symporter GltP

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 438 signal peptide" amino acids 1 to 24 (24 residues), see Phobius details transmembrane" amino acids 47 to 72 (26 residues), see Phobius details amino acids 84 to 106 (23 residues), see Phobius details amino acids 151 to 174 (24 residues), see Phobius details amino acids 206 to 228 (23 residues), see Phobius details amino acids 234 to 256 (23 residues), see Phobius details amino acids 322 to 348 (27 residues), see Phobius details amino acids 359 to 383 (25 residues), see Phobius details amino acids 394 to 411 (18 residues), see Phobius details PF00375: SDF" amino acids 8 to 411 (404 residues), 407.3 bits, see alignment E=3.6e-126

Best Hits

Swiss-Prot: 82% identical to GLTP_ECOLI: Proton/glutamate-aspartate symporter (gltP) from Escherichia coli (strain K12)

KEGG orthology group: K11102, proton glutamate symport protein (inferred from 98% identity to pct:PC1_1395)

MetaCyc: 82% identical to glutamate/aspartate : H+ symporter GltP (Escherichia coli K-12 substr. MG1655)
TRANS-RXN-122A; TRANS-RXN-162

Predicted SEED Role

"Proton/glutamate symport protein @ Proton/aspartate symport protein"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (438 amino acids)

>HER17_RS14145 glutamate/aspartate:proton symporter GltP (Pectobacterium carotovorum WPP14)
MKTQKISLAWQILIALVLGIALGAVLHEQQESRQWLISNILSPAGDIFIRLIKMIVVPIV
IATLIVGIAGVGDAKKLGRIGFKTILYFEIITTVAIILGITLANVFQPGHGIDMSTLTAV
DISQYQKTTEQVQSGSHSLVGTVLSLIPPNIFAAMAHGDMLPIIFFSVLFGLGLSSLPKD
HREPLLNVFRGVSETMFKVTHMIMRYAPVGVFALISVTVANFGFASLWPLAKLVMLVYAA
IFFFGLVVLGIVARLCKLRITILIRILKDELILAYSTASSETVLPRIIEKMEAYGAPKSI
TSFVVPTGYSFNLDGSTLYQSIAAIFIAQLYGIELSIGQEIVLVLTLMLTSKGIAGVPGV
SFVVLLATLGSVGIPLEGLAFIAGVDRILDMARTALNVVGNALAVLVIAKWENQFDEEKA
LAYERELKGISTEPAQQG