Protein Info for HER17_RS13210 in Pectobacterium carotovorum WPP14

Annotation: HlyD family type I secretion periplasmic adaptor subunit

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 442 transmembrane" amino acids 25 to 43 (19 residues), see Phobius details TIGR01843: type I secretion membrane fusion protein, HlyD family" amino acids 20 to 442 (423 residues), 383 bits, see alignment E=9.4e-119 PF00529: CusB_dom_1" amino acids 33 to 396 (364 residues), 50.6 bits, see alignment E=3.9e-17 PF13533: Biotin_lipoyl_2" amino acids 65 to 100 (36 residues), 25.1 bits, see alignment 2.9e-09 PF13437: HlyD_3" amino acids 294 to 396 (103 residues), 50.3 bits, see alignment E=8.6e-17

Best Hits

Swiss-Prot: 73% identical to PRTE_DICCH: Proteases secretion protein PrtE (prtE) from Dickeya chrysanthemi

KEGG orthology group: K12537, protease secretion protein HasE (inferred from 97% identity to pct:PC1_1556)

Predicted SEED Role

"ABC-type protease exporter, membrane fusion protein (MFP) family component PrtE/AprE" in subsystem Protein secretion by ABC-type exporters

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (442 amino acids)

>HER17_RS13210 HlyD family type I secretion periplasmic adaptor subunit (Pectobacterium carotovorum WPP14)
MSASEISEESMNQTARRDEKRAVRLGWLLVLAGFGGFLLWALFAPLDKGVMVNGSVVISG
NRKVVQHNQGGIVDKIQVKDGDRVEAGQILLTLNEVDARSASEGLDGQYLQLVAREGRLL
AEQQRLGDMVMTPRLQPLAEKPEMRVITALQRDLLHSRQQSLKLEAEGMRSSIAGMEASL
SAQRQVMSSKQKQRETLEQQLQGLRSLAAENYVPRNKMLENERLLAQLNGDIAQLAGDIN
RTRRDIEQQTLLIAQRQQEYDKEVNSELADVRALLSDVGSKKEKADFNLANIQMRAPVSG
TVVGLKVFTEGGVIAPGQTLLEIVPDDQPLFVDARLPVELVDKVWPGLPVELQFVAFNQS
TTPRVAGTVELLSADRLLDERDGSPYYSLRVQVDEAGKRALEGLEVKPGMPVQGFVRTGE
RSFVNYLFKPLMDRLHLALTEE