Protein Info for HER17_RS13035 in Pectobacterium carotovorum WPP14

Annotation: EmmdR/YeeO family multidrug/toxin efflux MATE transporter

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 466 transmembrane" amino acids 21 to 50 (30 residues), see Phobius details amino acids 66 to 87 (22 residues), see Phobius details amino acids 107 to 131 (25 residues), see Phobius details amino acids 150 to 169 (20 residues), see Phobius details amino acids 177 to 198 (22 residues), see Phobius details amino acids 204 to 230 (27 residues), see Phobius details amino acids 242 to 263 (22 residues), see Phobius details amino acids 291 to 315 (25 residues), see Phobius details amino acids 335 to 360 (26 residues), see Phobius details amino acids 372 to 390 (19 residues), see Phobius details amino acids 402 to 422 (21 residues), see Phobius details amino acids 428 to 449 (22 residues), see Phobius details PF01554: MatE" amino acids 30 to 190 (161 residues), 116.2 bits, see alignment E=6.1e-38 amino acids 260 to 421 (162 residues), 80.2 bits, see alignment E=7.2e-27 TIGR00797: MATE efflux family protein" amino acids 30 to 434 (405 residues), 230.6 bits, see alignment E=1.5e-72

Best Hits

Swiss-Prot: 65% identical to YEEO_ECOLI: Probable FMN/FAD exporter YeeO (yeeO) from Escherichia coli (strain K12)

KEGG orthology group: None (inferred from 97% identity to pwa:Pecwa_2872)

MetaCyc: 65% identical to FMN/FAD exporter (Escherichia coli K-12 substr. MG1655)
TRANS-RXN-272; TRANS-RXN0-595

Predicted SEED Role

"Putative sugar transporter"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (466 amino acids)

>HER17_RS13035 EmmdR/YeeO family multidrug/toxin efflux MATE transporter (Pectobacterium carotovorum WPP14)
MKKLKDTDWYKKRYSNRVLFWREISPLAFPIFIEGLCVVLMGVFSTFLVSWLGKEAMAAV
GLADSFNMVIIAFFTAVALGTAVVVAFSLGQRNRKQARSAARQSMSLLVLSSFLLVALVE
FAGSAIIDLIAGQADVQVKALALTFLRWTVWGYPAVAIALVGCGALRGAGNTKLPMVINI
GMNILNIAISSLLIYGAFSWDGLGFVGAGIGITISRYIGAVFVILTLMHGFNGALRIPFK
SYFAPFTLSILYEVLSIGIPASIESVMFNIGKLITQRFVADMGTEVIAGNFIAFSISTLI
NLPGNSLGAAATIIVGTRLGKGQIMQSTRQLKHIFWLSNIGLCVLAVLSVPSASFLASFY
TNEPEVIEVAKHLLWLNALFMPIWAASWVLPAGLKGAKDASYTMWVAMAGMWGCRVIAGY
ILGVMLGFGVIGVWMGMFFDWIVRGFFYYRRLMSGRWLWRYRPPTN