Protein Info for HER17_RS11165 in Pectobacterium carotovorum WPP14

Annotation: multidrug effflux MFS transporter

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 399 signal peptide" amino acids 1 to 33 (33 residues), see Phobius details transmembrane" amino acids 42 to 62 (21 residues), see Phobius details amino acids 70 to 91 (22 residues), see Phobius details amino acids 93 to 93 (1 residues), see Phobius details amino acids 98 to 116 (19 residues), see Phobius details amino acids 128 to 150 (23 residues), see Phobius details amino acids 159 to 178 (20 residues), see Phobius details amino acids 206 to 227 (22 residues), see Phobius details amino acids 242 to 260 (19 residues), see Phobius details amino acids 272 to 293 (22 residues), see Phobius details amino acids 305 to 328 (24 residues), see Phobius details amino acids 337 to 360 (24 residues), see Phobius details amino acids 366 to 384 (19 residues), see Phobius details TIGR00710: drug resistance transporter, Bcr/CflA subfamily" amino acids 3 to 379 (377 residues), 241.1 bits, see alignment E=1.3e-75 PF07690: MFS_1" amino acids 10 to 352 (343 residues), 154.4 bits, see alignment E=5.8e-49 PF00083: Sugar_tr" amino acids 37 to 181 (145 residues), 36 bits, see alignment E=6.2e-13

Best Hits

KEGG orthology group: K07552, MFS transporter, DHA1 family, bicyclomycin/chloramphenicol resistance protein (inferred from 95% identity to pwa:Pecwa_2254)

Predicted SEED Role

"Putative multidrug resistance protein"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (399 amino acids)

>HER17_RS11165 multidrug effflux MFS transporter (Pectobacterium carotovorum WPP14)
MQRFVLILLALVLLGPLGIDIYLPLIPAIAVALNSPESLIQSTVALFILIMGLGQLLAGP
LVDKYGRRPMALAGVIIYLIGAVMAALATSATLFILSRLFQGLAVCCTAVAIFSSVRDKL
NGDDAARTYGFLNGTLNIVPALAPLFGGLLAEALGWRAPFWFLAGYSILVLALVIRFLPE
TRPDSTLPVHGLPLRQYARLLSDRHFLGFASVNAGAMGMALTYVTFSPLVLMNEAQLTPL
EFSIAFGVNGFWIMLVSFFANRIIRKVGRPRCLAIGSLLMGAGFLSLLSGVVLLPEAMQN
TWPTYMLPVALACAGLAFLIGPSTSYALEPYSNEAGIASAMVGFVQMAGGAALGLIAMAL
PLPSKISLALVMLCAALLAIRARLLTRHHKGSITPLPRT