Protein Info for HER17_RS09880 in Pectobacterium carotovorum WPP14

Annotation: 4-aminobutyrate--2-oxoglutarate transaminase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR00700: 4-aminobutyrate transaminase
  • amino acids 8 to 419 (412 residues), 618.3 bits, E=2.7e-190
• PF00202: Aminotran_3
  • amino acids 21 to 419 (399 residues), 423 bits, E=5.1e-131

Best Hits

Swiss-Prot: 69% identical to PUUE_ECOLI: 4-aminobutyrate aminotransferase PuuE (puuE) from Escherichia coli (strain K12)

KEGG orthology group: K00823, 4-aminobutyrate aminotransferase [EC: 2.6.1.19] (inferred from 97% identity to pct:PC1_2233)

MetaCyc: 69% identical to 4-aminobutyrate aminotransferase PuuE (Escherichia coli K-12 substr. MG1655)
5-aminovalerate transaminase. [EC: 2.6.1.48]; 4-aminobutyrate transaminase. [EC: 2.6.1.48, 2.6.1.19]

Predicted SEED Role

"Gamma-aminobutyrate:alpha-ketoglutarate aminotransferase (EC 2.6.1.19)" (EC 2.6.1.19)

MetaCyc Pathways

• 4-aminobutanoate degradation II (2/2 steps found)
• 4-aminobutanoate degradation III (2/2 steps found)
• superpathway of 4-aminobutanoate degradation (2/3 steps found)
• L-lysine degradation X (4/6 steps found)
• 4-aminobutanoate degradation I (1/2 steps found)
• L-lysine degradation I (4/7 steps found)
• L-lysine degradation IV (2/5 steps found)
• GABA shunt I (1/4 steps found)
• GABA shunt II (1/4 steps found)
• L-lysine degradation III (2/6 steps found)
• superpathway of L-arginine and L-ornithine degradation (7/13 steps found)
• superpathway of L-arginine, putrescine, and 4-aminobutanoate degradation (5/11 steps found)
• 4-aminobutanoate degradation V (1/7 steps found)
• nicotine degradation I (pyridine pathway) (6/17 steps found)
• superpathway of L-lysine degradation (11/43 steps found)

KEGG Metabolic Maps

• Alanine and aspartate metabolism
• Butanoate metabolism
• Glutamate metabolism
• Lysine degradation
• Propanoate metabolism
• beta-Alanine metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 2.6.1.19 or 2.6.1.48

Protein Sequence (421 amino acids)

>HER17_RS09880 4-aminobutyrate--2-oxoglutarate transaminase (Pectobacterium carotovorum WPP14)
MKNSELNQRRLAATPRGVGVMCDFYAERAENSTLWDVEGREFIDFAAGIAVLNTGHRHPK
IVAAVREQLDRFTHTAYQIVPYGSYVTLAERINALAPIDGAAKTTFFTTGAEAVENAVKI
ARAYTKRPGVIAFNAAFHGRTLLTMTLTGKVAPYSTGFGPFPGSIFHALYPNEKQGITVE
QALESVERLMHTDIAADQVAAILLEPVQGEGGFHVAPPAFISGLRKLCDEHGILLIADEV
QTGFARTGKLFAMEYYAEKADLITMAKSLGGGFPISGVVGRADVMDAPSPGGLGGTYAGN
PLSVASALAVLDVIEEEKLCQRAQRLGAALVETLEKIKAQCPALVAIRAQGSMVAAEFND
PNTGKPSAEITRQFQKSALDAGLLLLTCGVHGNVIRFLYPLTVPDDQFSKAMSILTRVLT
R