Protein Info for HER17_RS07505 in Pectobacterium carotovorum WPP14

Annotation: mandelate racemase/muconate lactonizing enzyme family protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF02746: MR_MLE_N
  • amino acids 12 to 105 (94 residues), 76.5 bits, E=2e-25
• PF13378: MR_MLE_C
  • amino acids 147 to 368 (222 residues), 186.7 bits, E=4.9e-59

Best Hits

KEGG orthology group: None (inferred from 99% identity to eca:ECA2965)

Predicted SEED Role

"Gluconate dehydratase (EC 4.2.1.39)" in subsystem Entner-Doudoroff Pathway (EC 4.2.1.39)

MetaCyc Pathways

• Entner-Doudoroff pathway III (semi-phosphorylative) (7/9 steps found)
• Entner-Doudoroff pathway II (non-phosphorylative) (6/9 steps found)

KEGG Metabolic Maps

• Pentose phosphate pathway

Isozymes

No predicted isozymes

Use Curated BLAST to search for 4.2.1.39

Protein Sequence (393 amino acids)

>HER17_RS07505 mandelate racemase/muconate lactonizing enzyme family protein (Pectobacterium carotovorum WPP14)
MKITDVRVILANRYMFVEVTTDEGLTGIGESGAWGFLDASKGAVEALRTYLIGQDPLRIE
HHWQYMYRCWHFRGAAIMGAISAIDIALWDIAGKYYDTPVYNLLGGRCRDKARVYAHAGG
RTTEETIANLKKAKADGFTAIGHLTPFLDESRDTPYFTTHAKEIGEAIERIGLYREAVGN
DVDLCIEVHRRLKPADAVVFARGIEPFYPYFIEDPIGADNFDSMAEVADKINIPIATGER
LNNPQEFAMLIRRNAVAYVRPDVCMCGGITGAKKVAALAEANDLMVVPHNPLSPVSTAAC
LQIAVSIPNFALLEYPGDDQPALSEKFGATGVENGVRKKDVVKNTFKCVDGFMEIPTQSG
IGIELADDLENRFPYRRRGLKTRLHVDGSVVDQ