Protein Info for HER17_RS06035 in Pectobacterium carotovorum WPP14

Annotation: Fe-S protein assembly chaperone HscA

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 616 PF00012: HSP70" amino acids 21 to 600 (580 residues), 660.1 bits, see alignment E=2.7e-202 TIGR01991: Fe-S protein assembly chaperone HscA" amino acids 21 to 615 (595 residues), 879 bits, see alignment E=8.2e-269 PF06723: MreB_Mbl" amino acids 126 to 372 (247 residues), 40.6 bits, see alignment E=1.5e-14

Best Hits

Swiss-Prot: 96% identical to HSCA_PECAS: Chaperone protein HscA (hscA) from Pectobacterium atrosepticum (strain SCRI 1043 / ATCC BAA-672)

KEGG orthology group: K04044, molecular chaperone HscA (inferred from 96% identity to eca:ECA3233)

MetaCyc: 81% identical to iron-sulfur cluster biosynthesis chaperone HscA (Escherichia coli K-12 substr. MG1655)
3.6.4.-

Predicted SEED Role

"Chaperone protein HscA" in subsystem Protein chaperones

MetaCyc Pathways

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (616 amino acids)

>HER17_RS06035 Fe-S protein assembly chaperone HscA (Pectobacterium carotovorum WPP14)
MALLQISEPGLSAAPHQRRLAVGIDLGTTHSLVATVRSGEAQTLADSDGRDLLPSVVHYR
HDGHSVGWHARDNTAHDLENTVSSVKRLMGRSLDDIQQRYPHLPYRFHASDNGLPLIQTS
AGNLNPVQISADILSALATRAEAALGGVPDGVVITVPAYFDDAQRQGTKDAARLAGLHVL
RLLNEPTAAAIAYGLDSGKEGVIAIYDLGGGTFDISILRLSRGVFEVLATGGDSALGGDD
FDHLLAEWLREQAGIHDRDDRQLDHAFRDAAVKAKIALSSAETVRVDVAGWQGDITREQL
DALIAPLVKRTLLSCRRTLKDAGLTAEDVLEVVMVGGSTRVPLVRDQVGTFFGRTPLTSI
DPDKVVAIGAAIQADILVGNKPDSEMLLLDVIPLSLGLETMGGLVEKIIPRNTTIPVARA
QEFTTFKDGQSGMMIHVLQGEREMVADCRSLARFSLRGLPPLPAGGAHIRVTFQVDADGL
LSVTAMEKSTGVEASIQVKPSYGLSDTEIATMITDSMLNAKEDVGARRLAEQKVEAARVL
ESLQSALVADAELLSHEEKGVIVAASEHLHTMMQGSDPVAIEAAIKTVDQQTQEFAARRM
DASIRRALAGHSVDEV