Protein Info for HER17_RS05555 in Pectobacterium carotovorum WPP14

Annotation: pantoate--beta-alanine ligase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 284 TIGR00018: pantoate--beta-alanine ligase" amino acids 1 to 280 (280 residues), 366.9 bits, see alignment E=5.3e-114 PF02569: Pantoate_ligase" amino acids 3 to 278 (276 residues), 347 bits, see alignment E=3.2e-108 TIGR00125: cytidyltransferase-like domain" amino acids 24 to 62 (39 residues), 28.6 bits, see alignment 1.3e-10

Best Hits

Swiss-Prot: 94% identical to PANC_PECCP: Pantothenate synthetase (panC) from Pectobacterium carotovorum subsp. carotovorum (strain PC1)

KEGG orthology group: K01918, pantoate--beta-alanine ligase [EC: 6.3.2.1] (inferred from 94% identity to eca:ECA3322)

MetaCyc: 71% identical to pantothenate synthetase (Escherichia coli K-12 substr. MG1655)
Pantoate--beta-alanine ligase. [EC: 6.3.2.1]

Predicted SEED Role

"Pantoate--beta-alanine ligase (EC 6.3.2.1)" in subsystem Coenzyme A Biosynthesis (EC 6.3.2.1)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 6.3.2.1

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (284 amino acids)

>HER17_RS05555 pantoate--beta-alanine ligase (Pectobacterium carotovorum WPP14)
MLIIETPLLLRREVRRWRQEGKRIALVPTMGNLHDGHMTLVDEARARADIVIVSVFVNPM
QFERPDDLARYPRTLQEDCEKLNRRGADLVFAPSPDVIYPNGLESQTFVDVPGLSSMLEG
ASRPGHFRGVATIVSKLFNMVQPDVACFGEKDYQQLALIRQLVRDMGYDIDIIGVPIVRA
KDGLALSSRNGYLSAEERQRAPHVYQVMMDMATQLDNGDRQIDTLLEQAADKLCEAGFTP
DELFIRDADTLQPLSAASTRAVILMAAWLGKARLIDNHQVDLTV