Protein Info for HER17_RS04630 in Pectobacterium carotovorum WPP14

Annotation: S-methyl-5-thioribose kinase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF01636: APH
  • amino acids 32 to 285 (254 residues), 31.5 bits, E=8.3e-12
• TIGR01767: S-methyl-5-thioribose kinase
  • amino acids 33 to 397 (365 residues), 525.6 bits, E=4.1e-162

Best Hits

Swiss-Prot: 97% identical to MTNK_PECCP: Methylthioribose kinase (mtnK) from Pectobacterium carotovorum subsp. carotovorum (strain PC1)

KEGG orthology group: K00899, 5-methylthioribose kinase [EC: 2.7.1.100] (inferred from 96% identity to pwa:Pecwa_3446)

MetaCyc: 69% identical to S-methyl-5-thioribose kinase (Klebsiella pneumoniae)
S-methyl-5-thioribose kinase. [EC: 2.7.1.100]

Predicted SEED Role

"5-methylthioribose kinase (EC 2.7.1.100)" in subsystem Methionine Salvage (EC 2.7.1.100)

MetaCyc Pathways

• L-methionine salvage cycle I (bacteria and plants) (11/12 steps found)
• L-methionine salvage cycle II (plants) (9/11 steps found)
• S-methyl-5'-thioadenosine degradation I (2/2 steps found)
• 5'-deoxyadenosine degradation II (3/4 steps found)

KEGG Metabolic Maps

• Methionine metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 2.7.1.100

Protein Sequence (400 amino acids)

>HER17_RS04630 S-methyl-5-thioribose kinase (Pectobacterium carotovorum WPP14)
MSLYRIFTADDAVEYARQYGGVSQPQTLVAAEEIGDGNLNLVFKIKDEAGVSRVIVKQAL
PYVRCVGESWPLTLDRARIEAETLLTHARFCPQHTVTVLYHDPELAVMVQEDLSDHRIWR
SELVNGADYPQAAAQLGEYLAQTLFHTSDFYQHPHEKKAAVSQFTNPELCQITEDLFFTD
PYIDHERNQFDAALTPDVLALRDDRALKLAVAGLKHGFLSKAEALLHGDIHSGSIFVAEG
RLKAIDAEFGFYGPIGFDVGTAVGNLLLNYCGLPGLLAPREAAAGRERRLEDIRTLWQTF
SARFLALSESESRDPALAESGYAALFLQQVWRDAVGYCGTELIRRTIGLAHVADLDSIQE
TEARLACQRHAISLGRTLVLAAPHIADVDALLARVRQSGA