Protein Info for HER17_RS04075 in Pectobacterium carotovorum WPP14

Annotation: MFS transporter

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 transmembrane" amino acids 17 to 34 (18 residues), see Phobius details amino acids 54 to 78 (25 residues), see Phobius details amino acids 87 to 105 (19 residues), see Phobius details amino acids 110 to 127 (18 residues), see Phobius details amino acids 151 to 173 (23 residues), see Phobius details amino acids 179 to 198 (20 residues), see Phobius details amino acids 255 to 278 (24 residues), see Phobius details amino acids 291 to 316 (26 residues), see Phobius details amino acids 328 to 346 (19 residues), see Phobius details amino acids 352 to 373 (22 residues), see Phobius details amino acids 386 to 408 (23 residues), see Phobius details amino acids 416 to 435 (20 residues), see Phobius details PF07690: MFS_1" amino acids 25 to 318 (294 residues), 172.4 bits, see alignment E=1.4e-54 TIGR00893: D-galactonate transporter" amino acids 27 to 436 (410 residues), 517.5 bits, see alignment E=1.2e-159

Best Hits

Swiss-Prot: 81% identical to GUDP_ECOLI: Probable glucarate transporter (gudP) from Escherichia coli (strain K12)

KEGG orthology group: K03535, MFS transporter, ACS family, glucarate transporter (inferred from 98% identity to eca:ECA3577)

MetaCyc: 81% identical to galactarate/D-glucarate transporter GudP (Escherichia coli K-12 substr. MG1655)
TRANS-RXN0-203; TRANS-RXN0-204; TRANS-RXN0-523

Predicted SEED Role

"D-galactarate permease" in subsystem D-galactarate, D-glucarate and D-glycerate catabolism

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (450 amino acids)

>HER17_RS04075 MFS transporter (Pectobacterium carotovorum WPP14)
MNTVSSAAGAIQKRTNARYWIVVMLFIVTSFNYGDRATLSIAGSAMSKEIGLDAVGMGYI
FSAFSWAYVIGQIPGGWLLDRFGSKKVYFYSIFTWSIFTLLQGFVDIFSGAGIVISLFLL
RFMVGLCESPSFPGNSRIVAAWFPAQERGTAVAIFNSAQYFATVIFAPIMGWLVHAVGWA
HVFWFMGGLGIILSFVWLKVIHDPKDHPSVNQAELDYIEAGGALINMDAKGTKKEVVKGE
KWHQIKQLMQSRMMLGVYIGQYCINALTYFFITWFPLYLVQARGMSILKAGFVASVPAIC
GFVGGVLGGIISDYLMRRTNSLTFARKTPIVLGMLLSMSMVICNYVETEWVVIAVMSAAF
FGKGIGALGWAVMADTAPKEISGLSGGLFNMFGNASGIVTPIAIGYIIGMTGSFNGGLVY
VGIHALVAIVSYLFIVQDIKRIELKPFVKN