Protein Info for HER17_RS03710 in Pectobacterium carotovorum WPP14

Annotation: diaminopimelate decarboxylase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR01048: diaminopimelate decarboxylase
  • amino acids 9 to 418 (410 residues), 427.9 bits, E=1.5e-132
• PF02784: Orn_Arg_deC_N
  • amino acids 47 to 275 (229 residues), 197.5 bits, E=2.5e-62
• PF00278: Orn_DAP_Arg_deC
  • amino acids 211 to 376 (166 residues), 81.7 bits, E=3.9e-27

Best Hits

Swiss-Prot: 77% identical to DCDA_ECOLI: Diaminopimelate decarboxylase (lysA) from Escherichia coli (strain K12)

KEGG orthology group: K01586, diaminopimelate decarboxylase [EC: 4.1.1.20] (inferred from 99% identity to pct:PC1_3486)

MetaCyc: 77% identical to diaminopimelate decarboxylase (Escherichia coli K-12 substr. MG1655)
Diaminopimelate decarboxylase. [EC: 4.1.1.20]

Predicted SEED Role

"Diaminopimelate decarboxylase (EC 4.1.1.20)" in subsystem Lysine Biosynthesis DAP Pathway (EC 4.1.1.20)

MetaCyc Pathways

• aspartate superpathway (24/25 steps found)
• superpathway of L-lysine, L-threonine and L-methionine biosynthesis I (18/18 steps found)
• L-lysine biosynthesis I (9/9 steps found)
• superpathway of L-lysine, L-threonine and L-methionine biosynthesis II (13/15 steps found)
• L-lysine biosynthesis III (6/7 steps found)
• L-lysine biosynthesis VI (6/7 steps found)
• L-lysine biosynthesis II (7/9 steps found)

KEGG Metabolic Maps

• Biosynthesis of alkaloids derived from ornithine, lysine and nicotinic acid
• Lysine biosynthesis

Isozymes

Compare fitness of predicted isozymes for: 4.1.1.20

Use Curated BLAST to search for 4.1.1.20

Protein Sequence (420 amino acids)

>HER17_RS03710 diaminopimelate decarboxylase (Pectobacterium carotovorum WPP14)
MPHDLNDVTHALNAQSLRELPARFGCPVWAYDAQTIVNRIAQLRQFDTIRFAQKACSNTH
ILRLMREQGVKVDSVSLGEIERALMAGFVPGTDAHEIVFTADLLDRPTLQRVSELNIPVN
AGSVDMLEQLGQQSPGHPVWLRVNPGFGHGHSQKTNTGGENSKHGIWYGDLPLALAHIQR
YQLKLVGIHMHIGSGVDYGHLEQVCEAMVQQVVELGQDIEAISAGGGLSIPYRHGEEAID
TEHYYGLWNAAREKIAAHLGHPVTLEIEPGRFLVAESGVLVAEVRAIKSMGSRHFVLVDA
GFNDLMRPAMYGSYHHVSLLSGDGRDISQSTLRDSVIAGPLCESGDVFTQQAGGGVETFA
LPDAQVGDYLVFHDTGAYGASMSSNYNSRPLLPEVLFENGEPRLIRRRQTLDELLALEAL