Protein Info for HER17_RS03230 in Pectobacterium carotovorum WPP14

Annotation: GMP reductase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR01305: guanosine monophosphate reductase
  • amino acids 2 to 344 (343 residues), 653.9 bits, E=2.6e-201
• PF00478: IMPDH
  • amino acids 9 to 338 (330 residues), 250.3 bits, E=1.4e-78

Best Hits

Swiss-Prot: 92% identical to GUAC_YERE8: GMP reductase (guaC) from Yersinia enterocolitica serotype O:8 / biotype 1B (strain NCTC 13174 / 8081)

KEGG orthology group: K00364, GMP reductase [EC: 1.7.1.7] (inferred from 98% identity to pwa:Pecwa_3765)

MetaCyc: 87% identical to GMP reductase (Escherichia coli K-12 substr. MG1655)
GMP reductase. [EC: 1.7.1.7]

Predicted SEED Role

"GMP reductase (EC 1.7.1.7)" in subsystem Purine conversions (EC 1.7.1.7)

KEGG Metabolic Maps

• Purine metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 1.7.1.7

Protein Sequence (346 amino acids)

>HER17_RS03230 GMP reductase (Pectobacterium carotovorum WPP14)
MRIEEDLKLGFKDVLIRPKRSTLKSRSDVELERQFTFLHAGGNWSGVPIIAANMDTVGTF
SMAEVLASFDVLTAVHKHYSVEQWSQFVQRTPASVLRHVMVSTGTSDADFIKLKQILALS
TELKFICIDVANGYSEHFVTFLQKAREACPDKVICAGNVVTGEMVEELILSGADIVKVGI
GPGSVCTTRVKTGVGYPQLSAVIECADAAHGLGGQIVSDGGCAMPGDVAKAFGGGADFVM
LGGMLAGHDECEGTIVEENGEKMMLFYGMSSASAMERHVGGVAEYRAAEGKTVKLPLRGP
VDNTVRDILGGLRSACTYVGASRLKELTKRTTFIRVAEQENRIFNG