Protein Info for HER17_RS02575 in Pectobacterium carotovorum WPP14

Annotation: DNA mismatch repair endonuclease MutL

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 670 TIGR00585: DNA mismatch repair protein MutL" amino acids 1 to 310 (310 residues), 342.6 bits, see alignment E=1.5e-106 PF02518: HATPase_c" amino acids 21 to 77 (57 residues), 29.6 bits, see alignment 1.6e-10 PF13589: HATPase_c_3" amino acids 24 to 119 (96 residues), 51.3 bits, see alignment E=2.6e-17 PF01119: DNA_mis_repair" amino acids 214 to 329 (116 residues), 135.6 bits, see alignment E=1.3e-43 PF08676: MutL_C" amino acids 491 to 624 (134 residues), 98.9 bits, see alignment E=4.3e-32

Best Hits

Swiss-Prot: 93% identical to MUTL_PECCP: DNA mismatch repair protein MutL (mutL) from Pectobacterium carotovorum subsp. carotovorum (strain PC1)

KEGG orthology group: K03572, DNA mismatch repair protein MutL (inferred from 93% identity to pct:PC1_3723)

Predicted SEED Role

"DNA mismatch repair protein MutL" in subsystem DNA repair, bacterial MutL-MutS system

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (670 amino acids)

>HER17_RS02575 DNA mismatch repair endonuclease MutL (Pectobacterium carotovorum WPP14)
MPIQVLPPQLANQIAAGEVVERPASVVKELVENSLDAGATRIDIDIERGGAKLIRIRDNG
SGIGKDELTLALARHATSKIATLDDLEAIVSMGFRGEALASISSVSRLTLTSRTAEQSEA
WQAYAEGRDMAVTVKPAAHPVGTTLEVLDLFYNTPARRKFMRTEKTEFTHIDEVVRRIAL
ARFDVAITLHHNGKLMRQYRAAPDKSQYERRLGSICGATFLQHALAVSWQHGDLTIHGWV
AEPVGAKQLPDMQYCYVNQRMMRDRLINHAIRQAYQDQLSDDQQPAYVLYLEIDPHQVDV
NVHPAKHEVRFHQARLVHDFIYQAVMSVLQQASSPALGMTEPETGKPVQWQQENRTAAGE
NHFAQPSRTDSSPSYGGKTPRAGHSGSARESAYSGYQPENPYQKKQGELYKTLLQPTDNA
ASVPPPSGERISVPSNQVMSSDRVVPSTVSHDAPPNRTTVDNTAASNNKQRAPVESPLES
QSNGFGRVLTVYPPCYALLEYHKGLAMLSLSVAERYLKAVQLTPSEEGLRAQPLLIPQRL
TLSKSELGVLSAHHALLARFGIDVVVESQRATLRAVPLPLRQQNLQNLISELIGYLADYQ
TVETQQVEPGELASWMATRLQSEQESWSHSQAIQLLADVERLCPQLAKTPPSELLSMMDI
QDAIKALKHE