Protein Info for HER17_RS02400 in Pectobacterium carotovorum WPP14

Annotation: miniconductance mechanosensitive channel MscM

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1000 1107 signal peptide" amino acids 1 to 20 (20 residues), see Phobius details transmembrane" amino acids 478 to 496 (19 residues), see Phobius details amino acids 520 to 543 (24 residues), see Phobius details amino acids 562 to 585 (24 residues), see Phobius details amino acids 602 to 620 (19 residues), see Phobius details amino acids 632 to 652 (21 residues), see Phobius details amino acids 673 to 695 (23 residues), see Phobius details amino acids 701 to 721 (21 residues), see Phobius details amino acids 789 to 812 (24 residues), see Phobius details amino acids 832 to 852 (21 residues), see Phobius details amino acids 875 to 899 (25 residues), see Phobius details amino acids 906 to 933 (28 residues), see Phobius details PF12795: MscS_porin" amino acids 31 to 261 (231 residues), 201.2 bits, see alignment E=5.2e-63 PF12794: MscS_TM" amino acids 481 to 818 (338 residues), 376 bits, see alignment E=3.6e-116 PF21088: MS_channel_1st" amino acids 879 to 920 (42 residues), 41 bits, see alignment (E = 3.6e-14) PF00924: MS_channel_2nd" amino acids 922 to 987 (66 residues), 86.5 bits, see alignment 2.7e-28 PF21082: MS_channel_3rd" amino acids 995 to 1077 (83 residues), 44.3 bits, see alignment 5e-15

Best Hits

Swiss-Prot: 69% identical to MSCM_ECOLI: Miniconductance mechanosensitive channel MscM (mscM) from Escherichia coli (strain K12)

KEGG orthology group: None (inferred from 98% identity to eca:ECA3967)

Predicted SEED Role

No annotation

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (1107 amino acids)

>HER17_RS02400 miniconductance mechanosensitive channel MscM (Pectobacterium carotovorum WPP14)
MRLILTFLLGCLLSTATLAATAPNEAQLRQQLQQAEANKGAADQAKIVEEYQAALNTLQD
RKESLERATQYQRVIDDFPKLVQELRRQLNAEDGKPSSISESLSSNDLEQQLLQTSSQLL
EQARQLQQEQDRLREISDSLSQLPQQQTEASRMQSEAERRIQSLGTPATPLGQAQLVALQ
AESALRKSRVDELELAQLSASNRQELSRLRVELYKKRHDRLDLLQQDLRSRLNNMRQREA
EQALERTELLAEQSGDLPSVISKQLQVNRELSVALNQQAQRMDLIASQQRQAATHTIQVR
QALSTIREQAQWLGVSPILGETLRAQIARLPEMPKPQLLDSDMAQLRVQRLHFEDLINKP
QDLDNAKQDNGDPLTSAQQRILADQMRTQRDLLTSLISGCDSQILELTKLKVANNQLADA
LTETREAAHRDLFWVADVDPVTFAYPLKLVQDLTRLLSLDTLTQLGSALVMMVTSQETVL
PLLGALLLVGFSISSRRHYHAFMERASSRVGKVTLDHFMLTLRTVFWSILTALPLPVLWA
ALGYGLQNAWPYPIAVAIGDSVTATVPLMWLVMISASFSHPQGLFIVHFRWSPERVARAM
RYYRLSIAFIVPLIMALITFDKLNDREFSSTLGRLCFILLCMALSLVTTGLKRAGIPLYL
DKEGSGENSVNRAMWNILIAMPLVAALASCIGYLATAQALLARLETSVSIWFFLLVVYHI
IRRWMLIQRRRIAFDRAKQRRSEILAQRAKGEEDTPSASSHESSSEAVEEPVVDLDAISA
KSLQLVRSILTLIALVSVIALWSEIHSAFAFLENISLWDVSSTVKGVESVQAITLGSVLI
AILIFIITAQLVRNLPALLELAILQHLDLSPGSGYAITTISKYILMLIGCLMGFSLIGIE
WSKLQWLVAALGVGLGFGLQEIFANFISGLIILFEKPIRIGDTVTIRDLTGSVMRINTRA
TTISDWDRKEIIVPNKAFITEQFINWSLSDSVTRVVMTVPAPANANSQEVTELLMDAVKR
CSLILDTPEPEAFLVDLQQGIQIFELRVFAAEMGHRMPLRHELHQLILENYRKHNLELPF
PPFQVKMDNLSRSGKTLTPRQRTPGSL