Protein Info for HER17_RS02320 in Pectobacterium carotovorum WPP14

Annotation: TonB-dependent siderophore receptor

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 signal peptide" amino acids 1 to 25 (25 residues), see Phobius details PF07715: Plug" amino acids 54 to 159 (106 residues), 90.5 bits, see alignment E=9.9e-30 TIGR01783: TonB-dependent siderophore receptor" amino acids 55 to 700 (646 residues), 462.9 bits, see alignment E=1.1e-142 PF00593: TonB_dep_Rec" amino acids 251 to 669 (419 residues), 238.1 bits, see alignment E=3.6e-74

Best Hits

Swiss-Prot: 75% identical to FOXA_SALTS: Ferrioxamine B receptor (foxA) from Salmonella typhimurium (strain SL1344)

KEGG orthology group: K02014, iron complex outermembrane recepter protein (inferred from 95% identity to eca:ECA3985)

Predicted SEED Role

"Ferrichrome-iron receptor" in subsystem Iron acquisition in Vibrio or Transport of Iron

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (700 amino acids)

>HER17_RS02320 TonB-dependent siderophore receptor (Pectobacterium carotovorum WPP14)
MFRKTRLALVVGCFTSGFTVLALAQDTPSSSQGETLVVTSQTQRGATKLETPDIETPQAV
SIITRDQIQEQGATSVRQAVGYTPGVYNNQIGASNRFDYMVLRGFSDGSLDNVYLDGLKM
MGDTNSHSSLVIDPWFLDSIEVVRGPASVLYGRSSPGGIVALNSRQPSFDRSGQIKLFAG
NNAQRGAAFDVTGPLDDDERFAFRLGGMVREADTQFGPLKEERYAVAPSLLWRISDKTRL
EFMAYLQRDPEGGSHSGLPYEGTVVAHNGQKISNTFYEGEENYEKYDRKQNMVGYNFEHG
FDSGWAVRQKVRYLRTKVHLDQVYAYGWTQPNADTLTRYYSGSRESLSALTLDNQLDGSV
DTGAVNHRLLVGIDYQQRNNNMDWPSGSFPAIDAFNPVYGSGPTAMSGTLEKHKLQQTGI
YMQDQMSWERWRLTLGGRHDRVKVTHVNYTNDTHSELDKNNFSSRAALLYLFDNGLAPYV
SYSTAFTPTSFADDNGNVLEPMKGKQWEAGMKYQPEGSQDQYSLSVFRINQKNVATKVQP
NDPYRSVGEIESEGVELEAVSHITDNLRLQAAYTYTDIRYKKSSVAEQGKRAVYAPRNQA
SAWASYDVKSGPLDGLTLGSGVRYVNGVTSDRANTHTLPSYTLVDMAVGYDLSKVGLKGL
SAQLNVNNLTDKRYVAACNSLEFCYFGAERSVVGSVSYSF