Protein Info for HER17_RS02000 in Pectobacterium carotovorum WPP14

Annotation: two-component system response regulator PmrA

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 222 PF00072: Response_reg" amino acids 4 to 113 (110 residues), 90.5 bits, see alignment E=8.2e-30 PF00486: Trans_reg_C" amino acids 146 to 216 (71 residues), 67.6 bits, see alignment E=8.5e-23

Best Hits

Swiss-Prot: 96% identical to PMRA_PECPM: Transcriptional regulatory protein PmrA (pmrA) from Pectobacterium parmentieri

KEGG orthology group: K07771, two-component system, OmpR family, response regulator BasR (inferred from 96% identity to pwa:Pecwa_4016)

Predicted SEED Role

"Transcriptional regulatory protein basR/pmrA" in subsystem Lipid A modifications or Orphan regulatory proteins

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (222 amino acids)

>HER17_RS02000 two-component system response regulator PmrA (Pectobacterium carotovorum WPP14)
MKLLIVEDDKLLQEGLLLALSHEGYACDCAGTAKEADALISSAHYSLVILDLGLPDEDGL
TLLSRWRKNHYQHPVLILTARDKVNDRVSGLDVGADDYLAKPFALTELQARVRALIRRNQ
GSSNSKIQVDNITLDLNNQQVLLDDKPVVLTPKEFAILSRLVLKAGSQVHREVLHQDIYA
WNDDPSSNSLEVHIHNLRHKIGKDRIRTLRGFGYLLTKGEQP