Protein Info for HER17_RS01480 in Pectobacterium carotovorum WPP14

Annotation: sensor histidine kinase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 572 transmembrane" amino acids 7 to 25 (19 residues), see Phobius details amino acids 45 to 63 (19 residues), see Phobius details amino acids 75 to 95 (21 residues), see Phobius details amino acids 104 to 125 (22 residues), see Phobius details amino acids 137 to 164 (28 residues), see Phobius details amino acids 176 to 196 (21 residues), see Phobius details PF07694: 5TM-5TMR_LYT" amino acids 28 to 197 (170 residues), 200.2 bits, see alignment E=2.7e-63 PF06580: His_kinase" amino acids 372 to 449 (78 residues), 90.3 bits, see alignment E=1.2e-29

Best Hits

Swiss-Prot: 69% identical to BTSS_ECOL6: Sensor histidine kinase BtsS (btsS) from Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)

KEGG orthology group: K02478, two-component system, LytT family, sensor kinase [EC: 2.7.13.3] (inferred from 99% identity to pwa:Pecwa_4137)

MetaCyc: 69% identical to high-affinity pyruvate receptor (Escherichia coli K-12 substr. MG1655)
Histidine kinase. [EC: 2.7.13.3]

Predicted SEED Role

"Autolysin sensor kinase (EC 2.7.3.-)" (EC 2.7.3.-)

Isozymes

Compare fitness of predicted isozymes for: 2.7.13.3, 2.7.3.-

Use Curated BLAST to search for 2.7.13.3 or 2.7.3.-

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (572 amino acids)

>HER17_RS01480 sensor histidine kinase (Pectobacterium carotovorum WPP14)
MVSQIDLILSLLQQMCVYLVIAYLLSKTPLFIPLMQVTIRLPHKLVCYLVFSVFCIMGTY
FGLHIDDSIANTRATGAVLGGMLGGPSVGFLVGLTGGLHRYSMGGMTALACMLSTIAEGL
LGGLLHRYLARRNRIDLLFQPLVVGLTALVAEILQMAIILLVARPFDNAVELVRDIALPM
MITNTIGAAMFMRILLDRRAIFEKYTSAFSAKALQIAARAEGALRQGFNPQNSMRVARVL
YEELGVGAVAITDRDKLLAFIGLGDDHHNVGAPITSSHTRRAIDNNQVVYADGNEVSYTC
SVSSHCKLGSTLVIPLRGEDQRVVGTIKLYEPKNKLFSSINRTLGEGIAHLLSAQILTGR
FEQQKQLLAQSEIKLLHAQVNPHFLFNALNTLSAVIRRNPDHARQLVLSLSTFFRKNLKR
SNDEVSLNDELEHVNAYLEIEKARFADHLTVEISLPETLREARLPAFSLQPIVENAIKHG
ISQMIESGHIHISGRLHANTLELSVEDNAGTYQPRSGGDGLGMNLVDRRIKARYGNRYGI
TVVSEADKFTRVEVRVPLISPRQVLEKLDSVA