Protein Info for HER17_RS01245 in Pectobacterium carotovorum WPP14

Annotation: amino acid ABC transporter permease

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 223 transmembrane" amino acids 18 to 43 (26 residues), see Phobius details amino acids 55 to 78 (24 residues), see Phobius details amino acids 90 to 106 (17 residues), see Phobius details amino acids 188 to 209 (22 residues), see Phobius details TIGR01726: amino ABC transporter, permease protein, 3-TM region, His/Glu/Gln/Arg/opine family" amino acids 13 to 112 (100 residues), 90.7 bits, see alignment E=3.4e-30 PF00528: BPD_transp_1" amino acids 34 to 218 (185 residues), 89.9 bits, see alignment E=8.9e-30

Best Hits

Swiss-Prot: 57% identical to YXEN_BACSU: Probable amino-acid permease protein YxeN (yxeN) from Bacillus subtilis (strain 168)

KEGG orthology group: K02029, polar amino acid transport system permease protein (inferred from 98% identity to pwa:Pecwa_4185)

MetaCyc: 49% identical to cystine ABC transporter membrane subunit (Escherichia coli K-12 substr. MG1655)
TRANS-RXN-290 [EC: 7.4.2.12]; 7.4.2.12 [EC: 7.4.2.12]; 7.4.2.- [EC: 7.4.2.12]; 7.4.2.- [EC: 7.4.2.12]; 7.4.2.- [EC: 7.4.2.12]; 7.4.2.- [EC: 7.4.2.12]

Predicted SEED Role

"probable amino-acid ABC transporter permease protein"

Isozymes

No predicted isozymes

Use Curated BLAST to search for 7.4.2.12

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (223 amino acids)

>HER17_RS01245 amino acid ABC transporter permease (Pectobacterium carotovorum WPP14)
MNVDLAYLLKVFPQVLMYLPTTLFLAVVSMFFAMVLGLILALVRESKIVVVVKIVELYIS
LFRGIPSLVQLFIIYFGLPQLFPGLSNLDAMTAAIIGFSLKTSAYMAEIFRAGLASVDFG
QTEAGLSIGMSKAQVYRRIVLPQAMLNALPATGNTFISLIKDTSVAFALGVSELFAEGKM
IAAESLRFFETFLVVGLIYWLVIIVYSWLQKQLEKKLNHSLQR