Protein Info for HER17_RS00705 in Pectobacterium carotovorum WPP14

Annotation: VWA domain-containing protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 383 transmembrane" amino acids 237 to 260 (24 residues), see Phobius details PF05762: VWA_CoxE" amino acids 157 to 378 (222 residues), 169.8 bits, see alignment E=6e-54 PF13519: VWA_2" amino acids 223 to 314 (92 residues), 41.8 bits, see alignment E=1.5e-14

Best Hits

Swiss-Prot: 42% identical to YEHP_ECOLI: Uncharacterized protein YehP (yehP) from Escherichia coli (strain K12)

KEGG orthology group: None (inferred from 96% identity to pwa:Pecwa_0134)

Predicted SEED Role

"Mg-chelatase subunit ChlD"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (383 amino acids)

>HER17_RS00705 VWA domain-containing protein (Pectobacterium carotovorum WPP14)
MSAQDPQSDDKEKNGKRWRLILGHYADEALGKAAFDAHDLKVERTLDYLYRREYQRRGLK
QEGGRHGSLDQSQLTAVNWLNQARKLFPSSTFERMQSQAISRYEISHLFNDPQALQAMEP
TPALAKALLSLRGRMNEETREAVRDIIRKVVDEILRTLRPTFTNALTGRCNRFRRSPIPS
SQNFDWRATIAANLKHFDREKNRLVIETPHFNSRMQRHMPWDVILCVDQSASMSSSVMYA
AVCASILAALPAVRVSLIVFDTQVVDLSHLAHDPVDVLMTVQLGGGTNIAKAMQYCEQQV
QNPKRTIVTLISDFEEGGALNRLLSCVQRMHSQQITLLGLAALDDAAQPVYDTAIGQKLA
DRGMHVAALTPEHFAQWLAEVMR