Protein Info for HER17_RS00555 in Pectobacterium carotovorum WPP14

Annotation: aldolase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF00596: Aldolase_II
  • amino acids 21 to 197 (177 residues), 173 bits, E=3.1e-55

Best Hits

Swiss-Prot: 96% identical to OTNC_PECAS: 3-oxo-tetronate 4-phosphate decarboxylase (otnC) from Pectobacterium atrosepticum (strain SCRI 1043 / ATCC BAA-672)

KEGG orthology group: None (inferred from 97% identity to pct:PC1_0116)

MetaCyc: 65% identical to 3-dehydro-4-phosphotetronate decarboxylase (Haemophilus influenzae Rd KW20)
RXN-18589 [EC: 1.1.1.409, 4.1.1.104]; RXN-18588 [EC: 1.1.1.409, 4.1.1.104, 1.1.1.408]

Predicted SEED Role

"Ribulose-5-phosphate 4-epimerase and related epimerases and aldolases"

MetaCyc Pathways

• L-threonate degradation (3/4 steps found)
• D-erythronate degradation II (2/4 steps found)
• D-erythronate degradation I (1/3 steps found)
• D-threonate degradation (1/3 steps found)

Isozymes

No predicted isozymes

Use Curated BLAST to search for 1.1.1.408 or 1.1.1.409 or 4.1.1.104

Protein Sequence (218 amino acids)

>HER17_RS00555 aldolase (Pectobacterium carotovorum WPP14)
MSEQHHSTEAALNSEQRARAEMVKLGASFFQRGYATGSAGNLSLLLDDGTLLATPTGSCL
GELDAERLSKVSMSGEWISGDKPSKEVSFHLSIYRNDPECKAIVHLHSTYLTALSCLEGL
DTQDAIKPFTPYVVMRVGKVPVVPYYRPGDARLGEDLAKLASRYKAFLLANHGPVVTGKD
LRAAADNMEELEETAKLIFILGDRKIRYLTADEITELS