Protein Info for HEPCGN_27315 in Escherichia coli ECOR38

Annotation: thioredoxin

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 161 signal peptide" amino acids 1 to 27 (27 residues), see Phobius details PF08534: Redoxin" amino acids 25 to 152 (128 residues), 66.6 bits, see alignment E=4.5e-22 PF00578: AhpC-TSA" amino acids 25 to 138 (114 residues), 60.8 bits, see alignment E=2.6e-20 PF13098: Thioredoxin_2" amino acids 48 to 154 (107 residues), 27.8 bits, see alignment E=5.4e-10 PF13905: Thioredoxin_8" amino acids 49 to 138 (90 residues), 45.7 bits, see alignment E=1.4e-15

Best Hits

KEGG orthology group: None (inferred from 99% identity to cko:CKO_02051)

Predicted SEED Role

"Possible periplasmic thiredoxin"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (161 amino acids)

>HEPCGN_27315 thioredoxin (Escherichia coli ECOR38)
MRWHNVLLLAAAILISGCKEEKLAVGAPAPALAAFDLQGQESGLERWQGKAVYLNFWSAG
CGGCLAEMDTLEALSKKWGDKVVVVAVNTDPETVRINDLLAKHQITYPVVRDQLNITQER
YQVIGTPTSVLIDSEGRVLELHQGMRKPSELEATFARLAAR