Protein Info for HEPCGN_26595 in Escherichia coli ECOR38

Name: lsrC
Annotation: autoinducer 2 ABC transporter permease LsrC

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 282 transmembrane" amino acids 6 to 24 (19 residues), see Phobius details amino acids 30 to 52 (23 residues), see Phobius details amino acids 57 to 75 (19 residues), see Phobius details amino acids 95 to 117 (23 residues), see Phobius details amino acids 148 to 172 (25 residues), see Phobius details amino acids 184 to 211 (28 residues), see Phobius details amino acids 227 to 247 (21 residues), see Phobius details PF02653: BPD_transp_2" amino acids 5 to 241 (237 residues), 128.9 bits, see alignment E=1e-41

Best Hits

Swiss-Prot: 100% identical to LSRC_ECOSM: Autoinducer 2 import system permease protein LsrC (lsrC) from Escherichia coli (strain SMS-3-5 / SECEC)

KEGG orthology group: K10556, AI-2 transport system permease protein (inferred from 99% identity to eco:b1514)

MetaCyc: 99% identical to Autoinducer-2 ABC transporter membrane subunit LsrC (Escherichia coli K-12 substr. MG1655)
TRANS-RXN0-454 [EC: 7.6.2.13]

Predicted SEED Role

"Autoinducer 2 (AI-2) ABC transport system, membrane channel protein LsrC" in subsystem Autoinducer 2 (AI-2) transport and processing (lsrACDBFGE operon)

Isozymes

No predicted isozymes

Use Curated BLAST to search for 7.6.2.13

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (282 amino acids)

>HEPCGN_26595 autoinducer 2 ABC transporter permease LsrC (Escherichia coli ECOR38)
MQTSVSVGSITGMCAVLLGMLLNAGYSLPVACVATLLLGLLAGFFNGVLVAWLKIPAIVA
TLGTLGLYRGIMLLWTGGKWIEGLPAELKQLSAPLLFGVSAIGWLTIILVAFMAWLLAKT
AFGRSFYVTGDNLQGARQLGVRTEAIRIVAFSLNGCMAALAGIVFASQIGFIPNQTGTGL
EMKAIAACVLGGISLLGGSGAIIGAVLGAWFLTQIDSVLVLLRIPAWWNDFIAGMVLLAV
LVFDGRLRCALERNLRRQKYARFMMPPPSVKPASSGKKREAA