Protein Info for HEPCGN_23645 in Escherichia coli ECOR38

Name: cgsD
Annotation: transcriptional regulator CsgD

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 216 PF21155: VpsT-like_REC" amino acids 18 to 132 (115 residues), 31.2 bits, see alignment E=2.3e-11 PF00196: GerE" amino acids 155 to 210 (56 residues), 73.9 bits, see alignment E=6.3e-25

Best Hits

Swiss-Prot: 99% identical to CSGD_ECOLI: CsgBAC operon transcriptional regulatory protein (csgD) from Escherichia coli (strain K12)

KEGG orthology group: K04333, LuxR family transcriptional regulator, csgAB operon transcriptional regulatory protein (inferred from 99% identity to ebw:BWG_0889)

Predicted SEED Role

"Transcriptional regulator CsgD for 2nd curli operon" in subsystem Curli production

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (216 amino acids)

>HEPCGN_23645 transcriptional regulator CsgD (Escherichia coli ECOR38)
MFNEVHSIHGHTLLLITKPSLQAAALLQHLKQSLAITGKLHNIQRSLDDISSGSIILLDM
MEADKKLIHYWQDTLSRKNNNIKILLLNTPEDYPYRDIENWPHINGVFYAMEDQERVVNG
LQGVLRGECYFTQKLASYLITHSGNYRYNSTESALLTHREKEILNKLRIGASNNEIARSL
FISENTVKTHLYNLFKKIAVKNRTQAVSWANDNLRR