Protein Info for HEPCGN_23600 in Escherichia coli ECOR38

Annotation: GGDEF domain-containing protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 304 transmembrane" amino acids 42 to 62 (21 residues), see Phobius details amino acids 69 to 91 (23 residues), see Phobius details amino acids 106 to 124 (19 residues), see Phobius details PF17158: MASE4" amino acids 8 to 123 (116 residues), 113.8 bits, see alignment E=8.3e-37 TIGR00254: diguanylate cyclase (GGDEF) domain" amino acids 130 to 292 (163 residues), 155.7 bits, see alignment E=4.6e-50 PF00990: GGDEF" amino acids 131 to 288 (158 residues), 173.6 bits, see alignment E=2.8e-55

Best Hits

Predicted SEED Role

"Sensory box/GGDEF domain protein"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (304 amino acids)

>HEPCGN_23600 GGDEF domain-containing protein (Escherichia coli ECOR38)
VHNFVFCSWGPIVAHIFSSHYESYDLHIAELTNENGQVVWKASYVTIMIFMWLTLLSVNL
YFNGLRCDIWNGVSVIAFCAVLYNISLLFMSRYSVSIWYISRTIEVVSKLTVLVIFMCHI
FSALRVTKDIAHRDPLTNIFNRNYFFNELTVQSASAKKTPYCVMIMDIDHFKKVNDTWGH
PVGDQVIKTVVNIIGKSIRPDDLLARVGGEEFGVLLTEIDTECAKALAERIRENVERLTG
DNPEYAIPQKVTISIGAVVTQKNELNPKEIYQLADNALYEAKETGRNKVVVKEAEILINR
KDDE