Protein Info for HEPCGN_23495 in Escherichia coli ECOR38

Name: rutG
Annotation: pyrimidine utilization transport protein G

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 442 transmembrane" amino acids 33 to 54 (22 residues), see Phobius details amino acids 60 to 76 (17 residues), see Phobius details amino acids 83 to 103 (21 residues), see Phobius details amino acids 109 to 130 (22 residues), see Phobius details amino acids 142 to 162 (21 residues), see Phobius details amino acids 173 to 190 (18 residues), see Phobius details amino acids 197 to 219 (23 residues), see Phobius details amino acids 245 to 265 (21 residues), see Phobius details amino acids 286 to 307 (22 residues), see Phobius details amino acids 319 to 338 (20 residues), see Phobius details amino acids 348 to 373 (26 residues), see Phobius details amino acids 384 to 425 (42 residues), see Phobius details TIGR03616: pyrimidine utilization transport protein G" amino acids 1 to 428 (428 residues), 844.7 bits, see alignment E=1.2e-258 TIGR00801: uracil-xanthine permease" amino acids 26 to 424 (399 residues), 396.4 bits, see alignment E=1.6e-122 PF00860: Xan_ur_permease" amino acids 31 to 401 (371 residues), 349.7 bits, see alignment E=9e-109

Best Hits

Swiss-Prot: 99% identical to RUTG_ECOLI: Putative pyrimidine permease RutG (rutG) from Escherichia coli (strain K12)

KEGG orthology group: K09016, putative pyrimidine permease RutG (inferred from 99% identity to eco:b1006)

MetaCyc: 99% identical to pyrimidine:H+ symporter (Escherichia coli K-12 substr. MG1655)
RXN-5076; TRANS-RXN-132; TRANS-RXN-362

Predicted SEED Role

"Uracil permease" in subsystem De Novo Pyrimidine Synthesis or Pyrimidine utilization

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (442 amino acids)

>HEPCGN_23495 pyrimidine utilization transport protein G (Escherichia coli ECOR38)
MAMFGFPHWQLKSTSTESGVVAPDERLPFAQTAIMGVQHAVAMFGATVLMPILMGLDPNL
SILMSGIGTLLFFFITGGRVPSYLGSSAAFVGVVIAATGFNGQGINPNISIALGGIIACG
LVYTVIGLVVMKIGTRWIERLMPPVVTGAVVMAIGLNLAPIAVKSVSASAFDSWMAVMTV
LCIGLVAVFTRGMIQRLLILVGLIVACLLYGVMTNVLGLGKAVDFTLVSHAAWFGLPHFS
TPGFNSQAMMLIAPVAVILVAENLGHLKAVAGMTGRNMDPYMGRAFVGDGLATMLSGSVG
GSGVTTYAENIGVMAVTKVYSTLVFVAAAVIAMLLGFSPKFGALIHTIPAAVIGGASIVV
FGLIAVAGARIWVQNRIDLSQNGNLIMVAVTLVLGAGDFALTLGGFTLGGIGTATFGAIL
LNALLSRRLVDVPPPEVIHQEP