Protein Info for HEPCGN_23445 in Escherichia coli ECOR38

Name: torA
Annotation: trimethylamine-N-oxide reductase TorA

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 800 848 signal peptide" amino acids 1 to 43 (43 residues), see Phobius details TIGR02164: trimethylamine-N-oxide reductase TorA" amino acids 7 to 835 (829 residues), 1579.2 bits, see alignment E=0 PF18364: Molybdopterin_N" amino acids 55 to 95 (41 residues), 63.4 bits, see alignment 2.2e-21 TIGR00509: molybdopterin guanine dinucleotide-containing S/N-oxide reductases" amino acids 56 to 835 (780 residues), 1267.1 bits, see alignment E=0 PF00384: Molybdopterin" amino acids 99 to 572 (474 residues), 282.8 bits, see alignment E=6e-88 PF01568: Molydop_binding" amino acids 690 to 811 (122 residues), 86.7 bits, see alignment E=1.6e-28

Best Hits

Swiss-Prot: 99% identical to TORA_ECOLI: Trimethylamine-N-oxide reductase 1 (torA) from Escherichia coli (strain K12)

KEGG orthology group: K07811, trimethylamine-N-oxide reductase (cytochrome c) 1 [EC: 1.7.2.3] (inferred from 100% identity to ect:ECIAI39_2157)

MetaCyc: 99% identical to trimethylamine N-oxide reductase 1 (Escherichia coli K-12 substr. MG1655)
Trimethylamine-N-oxide reductase (cytochrome c). [EC: 1.7.2.3]; RXN0-5264 [EC: 1.7.2.3]

Predicted SEED Role

"Trimethylamine-N-oxide reductase (EC 1.6.6.9)" in subsystem trimethylamine N-oxide (TMAO) reductase (EC 1.6.6.9)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 1.6.6.9, 1.7.2.3

Use Curated BLAST to search for 1.6.6.9 or 1.7.2.3

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (848 amino acids)

>HEPCGN_23445 trimethylamine-N-oxide reductase TorA (Escherichia coli ECOR38)
MNNNDLFQASRRRFLAQLGGLTVAGMLGPSLLTPRRATAAQAATEAVISKEGILTGSHWG
AIRATVKDGRFVAAKPFELDKYPSKMIAGLPDHVHNAARIRYPMVRVDWLRKRHLSDTSQ
RGDNRFVRVSWDEALDMFYEELERVQKTHGPSALLTASGWQSTGMFHNASGMLAKAIALH
GNSVGTGGDYSTGAAQVILPRVVGSMEVYEQQTSWPLVLQNSKTIVLWGSDLLKNQQANW
WCPDHDVYEYYEQLKAKVAAGEIEVISIDPVVTSTHEYLGREHVKHIAVNPQTDVPLQLA
LAHTLYSENLYDKNFLTNYCVGFEQFLTYLLGEKDGQPKDAAWAEKLTGIDAETIRGMAR
QMAANRTQIIAGWCVQRMQHGEQWACMIVVLAAMLGQIGLPGGGFGFGWHYNGAGTPGRK
GVILSGFSGSTSISPVHDNSDYKGYSSTIPIARFIDAILEPGKVINWNGKSVKLPPLKMC
IFAGTNPFHRHQQINRIIEGWRKLETVIAIDNQWTSTCRFADIVLPATTQFERNDLDQYG
NHSNRGIIAMKQVVPPQFEARNDFDIFRELCRRFNREEAFTEGLDEMGWLKRIWQEGVQQ
GKGRGVHLPAFDDFWNNKEYVEFDHPQMFVRHQAFREDPDLEPLGTPSGLIEIYSKTIAD
MNYDDCQGHPMWFEKIERSHGGPGSQKYPLHLQSVHPDFRLHSQLCESETLRQQYTVAGK
EPVFINPQDASARGIRNGDVVRVFNARGQVLAGAVVSDRYAPGVARIHEGAWYDPDKGGE
PGALCKYGNPNVLTIDIGTSQLAQATSAHTTLVEIEKYNGTVEQVTAFNGPVEMVAQCEY
VPASQVKS