Protein Info for HEPCGN_23250 in Escherichia coli ECOR38

Name: pqiA
Annotation: membrane integrity-associated transporter subunit PqiA

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 417 transmembrane" amino acids 53 to 73 (21 residues), see Phobius details amino acids 99 to 122 (24 residues), see Phobius details amino acids 142 to 160 (19 residues), see Phobius details amino acids 165 to 186 (22 residues), see Phobius details amino acids 255 to 277 (23 residues), see Phobius details amino acids 304 to 328 (25 residues), see Phobius details amino acids 348 to 369 (22 residues), see Phobius details amino acids 377 to 399 (23 residues), see Phobius details TIGR00155: integral membrane protein, PqiA family" amino acids 1 to 408 (408 residues), 661 bits, see alignment E=3.5e-203 PF04403: PqiA" amino acids 49 to 200 (152 residues), 134.9 bits, see alignment E=1.2e-43 amino acids 253 to 408 (156 residues), 179.4 bits, see alignment E=2.3e-57

Best Hits

Swiss-Prot: 100% identical to PQIA_ECOL6: Intermembrane transport protein PqiA (pqiA) from Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)

KEGG orthology group: K03808, paraquat-inducible protein A (inferred from 100% identity to eco:b0950)

Predicted SEED Role

"Paraquat-inducible protein A" in subsystem Oxidative stress

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (417 amino acids)

>HEPCGN_23250 membrane integrity-associated transporter subunit PqiA (Escherichia coli ECOR38)
MCEHHHAAKHILCSQCDMLVALPRLEHGQKAACPRCGTTLTVAWDAPRQRPTAYALAALF
MLLLSNLFPFVNMNVAGVTSEITLLEIPGVLFSEDYASLGTFFLLFVQLVPAFCLITILL
LVNRAELPVRLKEQLARVLFQLKTWGMAEIFLAGVLVSFVKLMAYGSIGVGSSFLPWCLF
CVLQLRAFQCVDRRWLWDDIAPMPELRQPLKPGVTGIRQGLRSCSCCTAILPADEPVCPR
CGTKGYVRRRNSLQWTLALLVTSIMLYLPANILPIMVTDLLGSKMPSTILAGVILLWSEG
SYPVAAVIFLASIMVPTLKMIAIAWLCWDAKGHGKRDSERMHLIYEVVEFVGRWSMIDVF
VIAVLSALVRMGGLMSIYPAMGALMFALVVIMTMFSAMTFDPRLSWDRQPESEHEES