Protein Info for HEPCGN_23245 in Escherichia coli ECOR38

Name: uup
Annotation: ABC transporter ATP-binding protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 635 PF00005: ABC_tran" amino acids 19 to 185 (167 residues), 77.4 bits, see alignment E=1.6e-24 amino acids 335 to 469 (135 residues), 85.9 bits, see alignment E=4.1e-27 PF13304: AAA_21" amino acids 118 to 215 (98 residues), 28.5 bits, see alignment E=1.4e-09 PF12848: ABC_tran_Xtn" amino acids 224 to 297 (74 residues), 43.6 bits, see alignment E=2.5e-14 PF16326: ABC_tran_CTD" amino acids 561 to 629 (69 residues), 72.4 bits, see alignment E=2.8e-23

Best Hits

Swiss-Prot: 99% identical to UUP_ECOLI: ABC transporter ATP-binding protein uup (uup) from Escherichia coli (strain K12)

KEGG orthology group: None (inferred from 100% identity to ect:ECIAI39_2198)

Predicted SEED Role

"COG0488: ATPase components of ABC transporters with duplicated ATPase domains" in subsystem Folate Biosynthesis

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (635 amino acids)

>HEPCGN_23245 ABC transporter ATP-binding protein (Escherichia coli ECOR38)
MSLISMHGAWLSFSDAPLLDNAELHIEDNERVCLVGRNGAGKSTLMKILNREQGLDDGRI
IYEQDLIVARLQQDPPRNVEGSVYDFVAEGIEEQAEYLKRYHDISRLVMNDPSEKNLNEL
AKVQEQLDHHNLWQLENRINEVLAQLGLDPNVALSSLSGGWLRKAALGRALVSNPRVLLL
DEPTNHLDIETIDWLEGFLKTFNGTIIFISHDRSFIRNMATRIVDLDRGKLVTYPGNYDQ
YLLEKEEALRVEELQNAEFDRKLAQEEVWIRQGIKARRTRNEGRVRALKAMRRERSQRRE
VMGTAKMQVEEASRSGKIVFEMEDVCYQVYGKQLVKDFSAQVLRGDKIALIGPNGCGKTT
LLKLMLGQLQADSGRIHVGTKLEVAYFDQHRAELDPDKTVMDNLAEGKQEVMVNGKPRHV
LGYLQDFLFHPKRAMTPVRALSGGERNRLLLARLFLKPSNLLILDEPTNDLDVETLELLE
ELIDSYQGTVLLVSHDRQFVDNTVTECWIFEGGGKIGRYVGGYHDARGQQEQYVALKQPA
VKKIEEAAAPKAETVKRSSSKLSYKLQRELEQLPQLLEDLEAKLEALQTQVADASFFSQP
HEQTQKVLADMAAAEQELEQAFERWEYLEALKNGG