Protein Info for HEPCGN_21715 in Escherichia coli ECOR38

Name: intS
Annotation: prophage integrase IntS

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 385 transmembrane" amino acids 214 to 228 (15 residues), see Phobius details PF13356: Arm-DNA-bind_3" amino acids 2 to 86 (85 residues), 87.9 bits, see alignment E=5.8e-29 PF14659: Phage_int_SAM_3" amino acids 93 to 143 (51 residues), 25.9 bits, see alignment 1.4e-09 PF00589: Phage_integrase" amino acids 199 to 365 (167 residues), 131.7 bits, see alignment E=3.7e-42

Best Hits

Swiss-Prot: 99% identical to INTS_ECOLI: Prophage integrase IntS (intS) from Escherichia coli (strain K12)

KEGG orthology group: None (inferred from 100% identity to ect:ECIAI39_2501)

Predicted SEED Role

"Site-specific recombinase, phage integrase"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (385 amino acids)

>HEPCGN_21715 prophage integrase IntS (Escherichia coli ECOR38)
MLTVKQIEAAKPKEKPYRLLDGNGLYLYVPVSGKKVWQLRYKIDGKEKILTVGKYPLMTL
QEARDKAWTARKDISVGIDPVKAKKASSNNNSFSAIYKEWYEHKKQVWSVGYATELAKMF
DDDILPIIGGLEIQDIEPMQLLEVIRRFEDRGAMERANKARRRCGEVFRYAIVTGRAKYN
PAPDLADAMKGYRKKNFPFLPADQIPAFNKALATFSGSIVSLIATKVLRYTALRTKELRS
MQWKSVDFENRIITIDASVMKGRKIHVVPMSDQVVELLTTLSSITKPVSEFVFAGRNDKK
KPICDNAVLLVIKQIGYEGLESGHGFRHEFSTIMNEHEWPADAIEVQLAHANGGSVRGIY
NHAQYLDKRREMMQWWADWLDEKVE