Protein Info for HEPCGN_21315 in Escherichia coli ECOR38

Name: murR
Annotation: HTH-type transcriptional regulator MurR

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 285 PF01418: HTH_6" amino acids 1 to 76 (76 residues), 94.1 bits, see alignment E=6.3e-31 PF01380: SIS" amino acids 132 to 260 (129 residues), 79.5 bits, see alignment E=3.1e-26 PF13580: SIS_2" amino acids 175 to 217 (43 residues), 30.2 bits, see alignment 6.6e-11

Best Hits

Swiss-Prot: 100% identical to MURR_ECO7I: HTH-type transcriptional regulator MurR (murR) from Escherichia coli O7:K1 (strain IAI39 / ExPEC)

KEGG orthology group: None (inferred from 99% identity to sdy:SDY_2623)

Predicted SEED Role

"Sialic acid utilization regulator, RpiR family" in subsystem Sialic Acid Metabolism

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (285 amino acids)

>HEPCGN_21315 HTH-type transcriptional regulator MurR (Escherichia coli ECOR38)
MLYLTKIRNAESEFTGNEQKIADFLRANVSELKSVSSRKMAKQLGISQSSIVKFAQKLGA
QGFTELRMALIGEYSASREKTNATALHLHSSITSDDSLEVIARKLNREKEQALEQTCALF
DYARLQKIIEVISKAPFIQITGLGGSALVGRDLSFKLMKIGYRVTCEADTHVQATVSQAL
KKGDVQIAISYSGSKKEIVLCAEVARKQGATVIAITSLTDSPLRRLAHYTLDTVSGETEW
RSSSMSTRTAQNSVTDLLFVGLVQLNDVESLKMIERSSELTQRLK