Protein Info for HEPCGN_21155 in Escherichia coli ECOR38

Name: nudK
Annotation: GDP-mannose pyrophosphatase NudK

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR00052: nudix-type nucleoside diphosphatase, YffH/AdpP family
  • amino acids 2 to 186 (185 residues), 268 bits, E=1.9e-84
• PF00293: NUDIX
  • amino acids 45 to 173 (129 residues), 41.2 bits, E=8.2e-15

Best Hits

Swiss-Prot: 100% identical to NUDK_ECOSM: GDP-mannose pyrophosphatase NudK (nudK) from Escherichia coli (strain SMS-3-5 / SECEC)

KEGG orthology group: K12945, GDP-mannose pyrophosphatase NudK [EC: 3.6.1.-] (inferred from 98% identity to eco:b2467)

MetaCyc: 98% identical to GDP-mannose hydrolase (Escherichia coli K-12 substr. MG1655)
3.6.1.-

Predicted SEED Role

"GDP-mannose pyrophosphatase YffH" in subsystem Nudix proteins (nucleoside triphosphate hydrolases)

KEGG Metabolic Maps

• Folate biosynthesis
• Lipopolysaccharide biosynthesis
• Purine metabolism

Isozymes

Compare fitness of predicted isozymes for: 3.6.1.-

Use Curated BLAST to search for 3.6.1.-

Protein Sequence (191 amino acids)

>HEPCGN_21155 GDP-mannose pyrophosphatase NudK (Escherichia coli ECOR38)
MTQQITLIKDKILSDNYFTLHNITYDLTRKDGEVIRHKREVYDRGNGATILLYNAKKKTV
VLIRQFRVATWVNGNESGQLIETCAGLLDNDEPEVCIRKEAIEETGYEVGEVRKLFELYM
SPGGVTELIHFFIAEYSDSQRANAGGGVEDEDIEVLELPFSQALEMIKTGEIRDGKTVLL
LNYLQTSHLMD