Protein Info for HEPCGN_20815 in Escherichia coli ECOR38

Name: yfhM
Annotation: alpha2-macroglobulin

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1000 1100 1200 1300 1400 1500 1600 1652 signal peptide" amino acids 1 to 19 (19 residues), see Phobius details PF17970: bMG1" amino acids 59 to 163 (105 residues), 162.4 bits, see alignment 1.6e-51 PF21142: A2M_bMG2" amino acids 169 to 287 (119 residues), 171.4 bits, see alignment 3.7e-54 PF11974: bMG3" amino acids 289 to 381 (93 residues), 80.4 bits, see alignment 4.9e-26 PF01835: MG2" amino acids 388 to 479 (92 residues), 74.4 bits, see alignment 4.2e-24 PF17972: bMG5" amino acids 485 to 610 (126 residues), 131.8 bits, see alignment 1.1e-41 PF17962: bMG6" amino acids 638 to 741 (104 residues), 89.5 bits, see alignment 9.5e-29 PF07703: A2M_BRD" amino acids 759 to 905 (147 residues), 58.2 bits, see alignment E=6.4e-19 PF00207: A2M" amino acids 976 to 1057 (82 residues), 31.7 bits, see alignment 6.2e-11 PF07678: TED_complement" amino acids 1176 to 1281 (106 residues), 31.9 bits, see alignment 4.2e-11 PF21765: CUB_A2MG" amino acids 1442 to 1503 (62 residues), 96.1 bits, see alignment (E = 6.9e-31) PF17973: bMG10" amino acids 1504 to 1637 (134 residues), 83.3 bits, see alignment E=1e-26

Best Hits

Swiss-Prot: 98% identical to A2MG_ECOLI: Alpha-2-macroglobulin (yfhM) from Escherichia coli (strain K12)

KEGG orthology group: K06894, (no description) (inferred from 100% identity to ect:ECIAI39_2721)

Predicted SEED Role

"Alpha-2-macroglobulin"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (1652 amino acids)

>HEPCGN_20815 alpha2-macroglobulin (Escherichia coli ECOR38)
MKKLRVAACMLMLALAGCDNNDNAPTAVKKDAPSEVTKAVSSENASSAKLSAPERQKLAQ
QSAGKALTLLDLSEVQLDGAATLVLTFSIPLDPDQDFSRVIHVVDKKSGKVDGAWELSDN
LKELRLRHLEPKRDLIVTIGKEVKALNNATFSKDYEKTITTRDIQPSVGFASRGSLLPGK
VIEGLPVMALNVNNVDVNFFRVKPESLPAFISQWEYRNSLANWQSDKLLQMADLVYTGRF
DLNPARNTREKLLLPLGDIKPLQQAGVYLAVMNQAGRYDYSNPATLFTLSDIGVSAHRYH
NRLDIFTQSLENGAAQQGIEVSLLNEKGQTLTQATSDAQGHVQLENDKNAALLLARKDGQ
TTLLDLKLPALDLAEFNIAGAPGYSKQFFMFGPRDLYRPGETVILNGLLRDADGKALPDQ
PIKLDVIKPDGQVLRSVVSQPENGLYHFTWPLDSNAATGMWHIRANTGDNQYRMWDFHVE
DFMPERMALNLTGEKTPLTPNDEVKFSVVGYYLYGAPANGNTLQGQLFLRPLREAVSALP
GFEFGDIAAENLSRTLDEVQLTLDDKGRGEVSTESQWKEIHSPLQVIFQGSLLESGGRPV
TRRAEQAIWPADALPGIRPQFASKSVYDYRTDSTVKQPIVDEGSNAAFDIVYSDAQGVKK
AVSGLQVRLIRERRDYYWNWSEDEGWQSQFDQKDLIENEQTLDLQADETGKVSFPVEWGA
YRLEVKAPNEAVSSVRFWAGYSWQDNSDGGGAVRPDRVTLKLDKASYRPGDTIKLHIAAP
TAGKGYAMVESSEGPLWWQEIDVLAQGLDLTIPVDKTWNRHDLYLSTLVVRPGDKSRSAT
PKRAVGVLHLPLGDENRRLDLALETPTKMRPNQPLTVKIKASNKNGEMPKQVNVLVSAVD
SGVLNITDYVTPDPWQAFFGQKRYGADIYDIYGQVIEGQGRLAALRFGGDGDELKRGGKP
PVNHVNIVAQQALPVTLNEQGEGSVTLPIGDFNGELRVMAQAWTADDFGSNESKVIVAAP
VIAELNMPRFMASGDTSRLTLDITNLTDKPQKLNVALTASGLLELVSDSPAAVELAPGVR
TTLFIPVRALPGYGDGEIQATISGLALPGETVADQHKQWKIGVRPAFPAQTVNYGTALQP
GETWAIPADGLQNFSPVTLEGQLLLSGKPPLNIARYIKELKAYPYGCLEQTASGLFPSLY
TNAAQLQALGIKGDSDEKRRASVDIGISRLLQMQRDNGGFALWDKNGDEEYWLTAYVMDF
LVRAGEQGYSVPTDAINRGNERLLRYLQDPGMMSIPYADNLKASKFAVQSYAALVLARQQ
KAPLGALREIWEHRADAASGLPLLQLGVALKTMGDATRGEEAIALALKTPRNDERKWLGD
YGSPLRDNALMLSLLEENKLLPDEQNTLLNTLSQQAFGERWLSTQESNALFLAARTVQDL
PGKWQAQTSFSAEPLTGEKTLNSNLNSDQLATLQVSNSGDQPLWLRVDASGYPQSAPLPA
NNVLQIERHILGTDGKSKSLDSLRSGDLVLVWLQVKASNSVPDALVVDLLPAGLELENQN
LANGSASLEQSGGEVQNLLNQMQQASIKHIEFRDDRFVAAVAVDEYQPVTLVYLARAVTP
GTYQVPQPMVESMYVPQWRATGAAEDLLIVRP