Protein Info for HEPCGN_20480 in Escherichia coli ECOR38

Annotation: LysR substrate-binding domain-containing protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 162 PF00126: HTH_1" amino acids 3 to 62 (60 residues), 62.7 bits, see alignment E=2.5e-21 PF03466: LysR_substrate" amino acids 87 to 161 (75 residues), 58.2 bits, see alignment E=7.7e-20

Best Hits

Predicted SEED Role

"LysR family transcriptional regulator YfiE" in subsystem DNA-binding regulatory proteins, strays

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (162 amino acids)

>HEPCGN_20480 LysR substrate-binding domain-containing protein (Escherichia coli ECOR38)
MDLRRFITLKTVVEEGSFLRASQKLCCTQSTVTFHIQQLEQEFSVQLFEKIGRRMCLTRE
GKKLLPHIYELTRVMDTLREAAKKESDPDGELRVVSGETLLSYRMPQVLQRFRQRAPKVR
LSLQSLNCYVIRDALLNDEADVGVFYRVGNDDALNRRELGEQ