Protein Info for HEPCGN_19670 in Escherichia coli ECOR38

Name: nlpD
Annotation: murein hydrolase activator NlpD

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 379 signal peptide" amino acids 1 to 30 (30 residues), see Phobius details PF01476: LysM" amino acids 123 to 165 (43 residues), 46.2 bits, see alignment 3.4e-16 PF01551: Peptidase_M23" amino acids 279 to 372 (94 residues), 114.5 bits, see alignment E=2.1e-37

Best Hits

Swiss-Prot: 100% identical to NLPD_SHIFL: Murein hydrolase activator NlpD (nlpD) from Shigella flexneri

KEGG orthology group: K06194, lipoprotein NlpD (inferred from 100% identity to eco:b2742)

MetaCyc: 100% identical to murein hydrolase activator NlpD (Escherichia coli K-12 substr. MG1655)

Predicted SEED Role

"Lipoprotein NlpD"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (379 amino acids)

>HEPCGN_19670 murein hydrolase activator NlpD (Escherichia coli ECOR38)
MSAGSPKFTVRRIAALSLVSLWLAGCSDTSNPPAPVSSVNGNAPANTNSGMLITPPPKMG
TTSTAQQPQIQPVQQPQIQATQQPQIQPVQPVAQQPVQMENGRIVYNRQYGNIPKGSYSG
STYTVKKGDTLFYIAWITGNDFRDLAQRNNIQAPYALNVGQTLQVGNASGTPITGGNAIT
QADAAEQGVVIKPAQNSTVAVASQPTITYSESSGEQSANKMLPNNKPTATTVTAPVTVPT
ASTTEPTVSSTSTSTPISTWRWPTEGKVIETFGASEGGNKGIDIAGSKGQAIIATADGRV
VYAGNALRGYGNLIIIKHNDDYLSAYAHNDTMLVREQQEVKAGQKIATMGSTGTSSTRLH
FEIRYKGKSVNPLRYLPQR