Protein Info for HEPCGN_16840 in Escherichia coli ECOR38

Name: kdsD
Annotation: arabinose-5-phosphate isomerase KdsD

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 328 PF01380: SIS" amino acids 45 to 177 (133 residues), 125.7 bits, see alignment E=1.1e-40 TIGR00393: sugar isomerase, KpsF/GutQ family" amino acids 50 to 318 (269 residues), 447.8 bits, see alignment E=7.3e-139 PF00571: CBS" amino acids 206 to 261 (56 residues), 24.6 bits, see alignment E=2.6e-09 amino acids 273 to 325 (53 residues), 29.7 bits, see alignment 6.6e-11

Best Hits

Swiss-Prot: 100% identical to KDSD_ECOLI: Arabinose 5-phosphate isomerase KdsD (kdsD) from Escherichia coli (strain K12)

KEGG orthology group: K06041, arabinose-5-phosphate isomerase [EC: 5.3.1.13] (inferred from 100% identity to eco:b3197)

MetaCyc: 100% identical to D-arabinose 5-phosphate isomerase KdsD (Escherichia coli K-12 substr. MG1655)
Arabinose-5-phosphate isomerase. [EC: 5.3.1.13]

Predicted SEED Role

"Arabinose 5-phosphate isomerase (EC 5.3.1.13)" in subsystem KDO2-Lipid A biosynthesis (EC 5.3.1.13)

MetaCyc Pathways

Isozymes

Compare fitness of predicted isozymes for: 5.3.1.13

Use Curated BLAST to search for 5.3.1.13

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (328 amino acids)

>HEPCGN_16840 arabinose-5-phosphate isomerase KdsD (Escherichia coli ECOR38)
MSHVELQPGFDFQQAGKEVLAIERECLAELDQYINQNFTLACEKMFWCKGKVVVMGMGKS
GHIGRKMAATFASTGTPSFFVHPGEAAHGDLGMVTPQDVVIAISNSGESSEITALIPVLK
RLHVPLICITGRPESSMARAADVHLCVKVAKEACPLGLAPTSSTTATLVMGDALAVALLK
ARGFTAEDFALSHPGGALGRKLLLRVNDIMHTGDEIPHVKKTASLRDALLEVTRKNLGMT
VICDDNMMIEGIFTDGDLRRVFDMGVDVRQLSIADVMTPGGIRVRPGILAVEALNLMQSR
HITSVMVADGDHLLGVLHMHDLLRAGVV