Protein Info for HEPCGN_16495 in Escherichia coli ECOR38

Name: yhdJ
Annotation: adenine-specific DNA-methyltransferase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF01555: N6_N4_Mtase
  • amino acids 34 to 251 (218 residues), 217.3 bits, E=2.6e-68

Best Hits

Swiss-Prot: 99% identical to YHDJ_ECOLI: DNA adenine methyltransferase YhdJ (yhdJ) from Escherichia coli (strain K12)

KEGG orthology group: K07319, putative adenine-specific DNA-methyltransferase [EC: 2.1.1.72] (inferred from 99% identity to eco:b3262)

MetaCyc: 99% identical to DNA adenine methyltransferase (Escherichia coli K-12 substr. MG1655)
Site-specific DNA-methyltransferase (adenine-specific). [EC: 2.1.1.72]

Predicted SEED Role

"Adenine-specific methyltransferase (EC 2.1.1.72)" (EC 2.1.1.72)

Isozymes

Compare fitness of predicted isozymes for: 2.1.1.72

Use Curated BLAST to search for 2.1.1.72

Protein Sequence (294 amino acids)

>HEPCGN_16495 adenine-specific DNA-methyltransferase (Escherichia coli ECOR38)
MRTGCEPTRFGNEAKTIIQGDALTELKKIPAESVDLIFADPPYNIGKNFDGLIEAWKEDL
FIDWLFEVIAECHRVLKKQGSMYIMNSTENMPFIDLQCRKLFTIKSRIVWSYDSSGVQAK
KHYGSMYEPILMMVKDAKNYTFNGDAILVEAKTGSQRALIDYRKNPPQPYNHQKVPGNVW
DFPRVRYLMDEYENHPTQKPEALLKRIILASSNPGDIVLDPFAGSFTTGAVAAASGRKFI
GIEINSEYIKMGLRRLDVASHYSAEELAKVKKRKTGNLSKRSRLSEVDPDLIAK