Protein Info for HEPCGN_14155 in Escherichia coli ECOR38

Name: emrE
Annotation: QacE family quaternary ammonium compound efflux SMR transporter

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 133 signal peptide" amino acids 1 to 22 (22 residues), see Phobius details transmembrane" amino acids 37 to 54 (18 residues), see Phobius details amino acids 66 to 86 (21 residues), see Phobius details amino acids 92 to 111 (20 residues), see Phobius details PF00893: Multi_Drug_Res" amino acids 8 to 101 (94 residues), 73.2 bits, see alignment E=1e-24

Best Hits

Swiss-Prot: 43% identical to QACE_ECOLX: Quaternary ammonium compound-resistance protein QacE (qacE) from Escherichia coli

KEGG orthology group: K03297, small multidrug resistance protein, SMR family (inferred from 98% identity to efe:EFER_2000)

Predicted SEED Role

"Ethidium bromide-methyl viologen resistance protein EmrE"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (133 amino acids)

>HEPCGN_14155 QacE family quaternary ammonium compound efflux SMR transporter (Escherichia coli ECOR38)
MSSKTKCWLWMLLVILSETSATSTLKMFDNSEGMTKTLLLALIVVLYCICYYSLSRAVKD
IPVGLAYATWSGTGILMVSTLGILFYGQHPDTAAIIGMVIIASGIIIMNLFSKMGSEEAE
ETPVTNLDKKIAN