Protein Info for HEPCGN_14145 in Escherichia coli ECOR38

Name: dsdC
Annotation: DNA-binding transcriptional regulator DsdC

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 314 TIGR02036: D-serine deaminase transcriptional activator" amino acids 8 to 307 (300 residues), 597.2 bits, see alignment E=2.5e-184 PF00126: HTH_1" amino acids 18 to 76 (59 residues), 77.9 bits, see alignment E=4.5e-26 PF03466: LysR_substrate" amino acids 99 to 306 (208 residues), 105 bits, see alignment E=3.8e-34

Best Hits

Swiss-Prot: 99% identical to DSDC_ECOLI: HTH-type transcriptional regulator DsdC (dsdC) from Escherichia coli (strain K12)

KEGG orthology group: K13636, LysR family transcriptional regulator, D-serine deaminase activator (inferred from 100% identity to ect:ECIAI39_4219)

Predicted SEED Role

"D-serine dehydratase transcriptional activator" in subsystem Glycine and Serine Utilization

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (314 amino acids)

>HEPCGN_14145 DNA-binding transcriptional regulator DsdC (Escherichia coli ECOR38)
MEPLREIRNRLLNGWQLSKLHTFEVAARHQSFALAAEELSLSPSAVSHRINQLEEELGIQ
LFVRSHRKVELTHEGKRVYWALKSSLDTLNQEILDIKNQELSGTLTLYSRPSIAQCWLVP
ALGDFTRRYPSISLTVLTGNDNVNLQRAGIDLAIYFDDAPSAQLTHHFLMDEEILPVCSP
EYAQRHDLTNTVINLSHCTLLHDRQAWSNDSGTDEWHSWAQHYAVNLPTSSGIGFDRSDL
AVIAAMNHIGVAMGRKRLVQKRLASGELVAPFGDMTVKCHQHYYITTLPGRQWPKIEAFI
TWLREQVCQSCQYQ