Protein Info for HEPCGN_14100 in Escherichia coli ECOR38

Annotation: pseudouridine kinase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF00294: PfkB
  • amino acids 5 to 295 (291 residues), 222.7 bits, E=3.6e-70

Best Hits

Swiss-Prot: 79% identical to PSUK_ECOLI: Pseudouridine kinase (psuK) from Escherichia coli (strain K12)

KEGG orthology group: None (inferred from 100% identity to ect:ECIAI39_4229)

MetaCyc: 82% identical to pseudouridine kinase (Escherichia coli UTI89)
Pseudouridine kinase. [EC: 2.7.1.83]

Predicted SEED Role

"Pseudouridine kinase (EC 2.7.1.83)" (EC 2.7.1.83)

MetaCyc Pathways

• pseudouridine degradation (2/2 steps found)

KEGG Metabolic Maps

• Pyrimidine metabolism

Isozymes

Compare fitness of predicted isozymes for: 2.7.1.83

Use Curated BLAST to search for 2.7.1.83

Protein Sequence (311 amino acids)

>HEPCGN_14100 pseudouridine kinase (Escherichia coli ECOR38)
MCDKEYIITIGSANIDIAGYSYASLNYADSNPGKIKFTPGGVGRNIAHNLALLGKNSWLM
SAVGDDFYGQSLLAQTTQSGVNVDKCLIVNGENTSSYLSLLDKTGEMLVAINDMTISEHI
SAEFLSQHIDFIQGAKVIVADCNISESTLVWLLNNAGKVPVFVDPVSAWKCVKIREHLAQ
IHTLKPNRLEAETLSGISLSDRNDAEKVAVWFHTHGLNRLVLSMGGDGVYYSELYGASGW
SPPVKTQVVNVTGAGDAMMAGLASCWVDNMPFIDSIRFAQGCSSMALASEYTNNPELSVA
NVKSLVEKQNV