Protein Info for HEPCGN_13990 in Escherichia coli ECOR38

Annotation: SycD/LcrH family type III secretion system chaperone

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 165 TIGR02552: type III secretion low calcium response chaperone LcrH/SycD" amino acids 24 to 153 (130 residues), 113 bits, see alignment E=4.4e-37 PF07720: TPR_3" amino acids 39 to 72 (34 residues), 38.1 bits, see alignment 6e-14 amino acids 74 to 97 (24 residues), 29.2 bits, see alignment 3.9e-11

Best Hits

Swiss-Prot: 44% identical to YGEG_ECOLI: Uncharacterized protein YgeG (ygeG) from Escherichia coli (strain K12)

KEGG orthology group: None (inferred from 98% identity to ecm:EcSMS35_4018)

Predicted SEED Role

"Type III secretion chaperone protein for YopD (SycD)" in subsystem Type III secretion systems, extended

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (165 amino acids)

>HEPCGN_13990 SycD/LcrH family type III secretion system chaperone (Escherichia coli ECOR38)
MESTNLDLEENKEIASKFERALGMGATLAELHGITPDTLEGVYAYAYNFYEKGRLDEAEL
FFKFLCIYDFQNYNYLKGYAAVCQLKKDYQKAFDMYHICLMLSPDNDFSLVYYMGQCQMG
LKNIKMATELFNTVVTYSQNEKIKEMATAYLELLTANTEEEVQTE