Protein Info for HEPCGN_13340 in Escherichia coli ECOR38

Name: ilvY
Annotation: HTH-type transcriptional activator IlvY

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 319 transmembrane" amino acids 242 to 265 (24 residues), see Phobius details PF00126: HTH_1" amino acids 26 to 85 (60 residues), 80.4 bits, see alignment E=7.6e-27 PF03466: LysR_substrate" amino acids 112 to 316 (205 residues), 126.5 bits, see alignment E=9.7e-41

Best Hits

Swiss-Prot: 99% identical to ILVY_ECOLI: HTH-type transcriptional regulator IlvY (ilvY) from Escherichia coli (strain K12)

KEGG orthology group: K02521, LysR family transcriptional regulator, positive regulator for ilvC (inferred from 98% identity to eum:ECUMN_4299)

Predicted SEED Role

"HTH-type transcriptional regulator IlvY" in subsystem Alanine biosynthesis

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (319 amino acids)

>HEPCGN_13340 HTH-type transcriptional activator IlvY (Escherichia coli ECOR38)
LRKLIYSQRHIAISATSTLRAAPLDLRDLKTFLHLAESRHFGRSARAMHVSPSTLSRQIQ
RLEDDLGQPLFVRDNRTVTLTEAGEELRVFAQQTLLQYQQLRHTIDQQGPSLSGELHIFC
SVTAAYSHLPPILDRFRAEHPSVEIKLTTGDAADAMEKVVTGEADLAIAGKPETLPGAVA
FSMLENLAVVLIAPALPCPVRNQVSAEKPDWSTVPFIMADQGPVRRRIELWFRRNKISNP
MIYATVGGHEAMVSMVALGCGVALLPEVVLENSPEPVRNRVMILERSDEKTPFELGVCVQ
KKRLHEPLIEAFWKILPNH