Protein Info for HEPCGN_12980 in Escherichia coli ECOR38

Annotation: C4-dicarboxylate ABC transporter permease

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 496 transmembrane" amino acids 20 to 50 (31 residues), see Phobius details amino acids 61 to 83 (23 residues), see Phobius details amino acids 109 to 133 (25 residues), see Phobius details amino acids 139 to 162 (24 residues), see Phobius details amino acids 167 to 185 (19 residues), see Phobius details amino acids 197 to 220 (24 residues), see Phobius details amino acids 233 to 254 (22 residues), see Phobius details amino acids 259 to 280 (22 residues), see Phobius details amino acids 316 to 339 (24 residues), see Phobius details amino acids 355 to 378 (24 residues), see Phobius details amino acids 387 to 408 (22 residues), see Phobius details amino acids 410 to 427 (18 residues), see Phobius details amino acids 437 to 442 (6 residues), see Phobius details amino acids 466 to 487 (22 residues), see Phobius details PF01970: TctA" amino acids 21 to 439 (419 residues), 508.8 bits, see alignment E=5e-157

Best Hits

KEGG orthology group: K07793, putative tricarboxylic transport membrane protein (inferred from 99% identity to efe:EFER_3654)

Predicted SEED Role

"Tricarboxylate transport membrane protein TctA"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (496 amino acids)

>HEPCGN_12980 C4-dicarboxylate ABC transporter permease (Escherichia coli ECOR38)
MFESELLTQGFSTLLNNPQALLFATFGVMLGIVIGALPGLTATMGVAILLPFTYGMEPVS
GLLMICGVFFGGVYGGSITAILLKIPGTPAAAATAIDGYELTKQGKAGLALSAATFSSFS
GGTLSIIVLMFLSPVLASWALKFSASESFALATFGLSIIASISGESLIKGLIAGVGGLLI
ATIGLDPMGGFPRFTGGFVELMNVPFIPVMIGLFAASEAFRSMEQNQQIRQGAKVAIGSL
LLPWQILRRIALTILRSSGLGVFIGMIPGAGADIAAFVAYNETRRFSKTPENFGKGEIKA
VASCEAGANGCTGGALLPMLTLGIPGDAVTAIMLGALTLQGMQPGPLMFTDHGDMVYTLF
VGMIFCYFMLLVLGLLSLKVIGNVVKIPGNILTPMILALCVVGTYALNNSLFDVGIMLIA
GVVGYFMQKGGYPASPVVLALIMGPMAESNFRRALSLSGGSLDFLYTRPITLALLTLAAF
TLLTPIIRKIMRLRRQ