Protein Info for HEPCGN_10820 in Escherichia coli ECOR38

Name: gltS
Annotation: sodium/glutamate symporter

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 401 transmembrane" amino acids 6 to 26 (21 residues), see Phobius details amino acids 34 to 51 (18 residues), see Phobius details amino acids 63 to 81 (19 residues), see Phobius details amino acids 93 to 116 (24 residues), see Phobius details amino acids 156 to 178 (23 residues), see Phobius details amino acids 217 to 236 (20 residues), see Phobius details amino acids 242 to 262 (21 residues), see Phobius details amino acids 274 to 294 (21 residues), see Phobius details amino acids 303 to 326 (24 residues), see Phobius details amino acids 336 to 355 (20 residues), see Phobius details amino acids 370 to 394 (25 residues), see Phobius details PF03616: Glt_symporter" amino acids 2 to 366 (365 residues), 546.5 bits, see alignment E=1.3e-168 TIGR00210: sodium/glutamate symporter" amino acids 3 to 396 (394 residues), 515.7 bits, see alignment E=3.5e-159

Best Hits

Swiss-Prot: 57% identical to GLTS_HAEIN: Sodium/glutamate symporter (gltS) from Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)

KEGG orthology group: K03312, glutamate:Na+ symporter, ESS family (inferred from 100% identity to eoi:ECO111_p1-102)

MetaCyc: 52% identical to glutamate:sodium symporter (Escherichia coli K-12 substr. MG1655)
TRANS-RXN-122

Predicted SEED Role

"Sodium/glutamate symport protein" in subsystem ZZ gjo need homes

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (401 amino acids)

>HEPCGN_10820 sodium/glutamate symporter (Escherichia coli ECOR38)
MILDASYTLLVACIALLIGMFVVKFTPFLQKNHIPEAVVGGFIVAIVLLIIDKTSGYSFT
FDASLQSLLMLTFFSSIGLSSDFSRLIKGGKPLVLLTIAVTILIAIQNTVGMSMAVMMNE
SPFIGLIAGSITLTGGHGNAGAWGPILADKYGVTGAVELAMACATLGLVLGGLVGGPVAR
HLLKKVSIPKTTEQERDTIVEAFEQPSVKRKINANNVIETISMLIICIVVGGYISALFKD
TFLQLPTFVWCLFVGIIIRNTLTHVFKHEVFEPTVDVLGSVALSLFLAMALMSLKFGQLA
SMAGPVLIIIAVQTVVMVLFACFVTFKMMGKDYDAVVISAGHCGFGMGATPTAIANMQTV
TKAFGPSHKAFLVVPMVGAFIVDISNSILIKIFIEIGTYFT