Protein Info for HEPCGN_10700 in Escherichia coli ECOR38

Annotation: lactate permease

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 518 transmembrane" amino acids 5 to 22 (18 residues), see Phobius details amino acids 28 to 47 (20 residues), see Phobius details amino acids 58 to 80 (23 residues), see Phobius details amino acids 109 to 138 (30 residues), see Phobius details amino acids 147 to 168 (22 residues), see Phobius details amino acids 183 to 203 (21 residues), see Phobius details amino acids 212 to 231 (20 residues), see Phobius details amino acids 238 to 256 (19 residues), see Phobius details amino acids 289 to 309 (21 residues), see Phobius details amino acids 338 to 363 (26 residues), see Phobius details amino acids 378 to 401 (24 residues), see Phobius details amino acids 410 to 428 (19 residues), see Phobius details amino acids 497 to 516 (20 residues), see Phobius details TIGR00795: transporter, lactate permease (LctP) family" amino acids 2 to 511 (510 residues), 407 bits, see alignment E=7.2e-126 PF02652: Lactate_perm" amino acids 7 to 510 (504 residues), 432.8 bits, see alignment E=1.1e-133

Best Hits

KEGG orthology group: K03303, lactate transporter, LctP family (inferred from 98% identity to ecq:ECED1_5018)

Predicted SEED Role

"L-lactate permease" in subsystem Lactate utilization

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (518 amino acids)

>HEPCGN_10700 lactate permease (Escherichia coli ECOR38)
MHDYLLFLLGLTPLLAMIILILKVKMPIHYAVLSTLLITLILGGVFWQTPVMDMGSAVVY
GAIKGLWPIVIVILAAIYSYNLMNATKSMDVLRNVLASVSDDKRIQVLLISWCFGGFLEA
AAGYGTAVAIPIGILIALGFNPLKAAIASLVANTVPTAFGAVGIPVSVLAEQVNLPVTTL
SGTIILQLALFNILLPFVIVAIIGGGMKAIRGVGLITLMCGISTLIPQYLVAVNLGAELP
AFAGSLVSLIVIVFMAKNRKEKTEPEFLIEASADSASALSYSRGELFRACSIYILIFLFI
LLCSPLFPTIKSAVSQIASSLSFSLSNGSNLSMKIEWVATPGVLIIIASVIGGLIQKASL
SCLLNVFVSTVKQLKNSIIAISAIVAMATVMDVCGLIGTLAQSLVDLTGGAYLFIAPVIG
ALGTFVTGSDTNSNILFGKLQTTAAEKLHVDPLWLAAANTSGATGGKMISPQSIAIAVSA
TRMDGQGSVIMSGTLKYCFAYIVILGLKVGLVYHLFMA