Protein Info for HEPCGN_10665 in Escherichia coli ECOR38

Name: dcuA
Annotation: anaerobic C4-dicarboxylate transporter DcuA

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 433 transmembrane" amino acids 6 to 37 (32 residues), see Phobius details amino acids 47 to 67 (21 residues), see Phobius details amino acids 87 to 112 (26 residues), see Phobius details amino acids 130 to 153 (24 residues), see Phobius details amino acids 165 to 190 (26 residues), see Phobius details amino acids 225 to 243 (19 residues), see Phobius details amino acids 255 to 277 (23 residues), see Phobius details amino acids 289 to 307 (19 residues), see Phobius details amino acids 328 to 346 (19 residues), see Phobius details amino acids 358 to 382 (25 residues), see Phobius details amino acids 410 to 431 (22 residues), see Phobius details TIGR00770: transporter, anaerobic C4-dicarboxylate uptake (Dcu) family" amino acids 5 to 433 (429 residues), 697.1 bits, see alignment E=5e-214 PF03605: DcuA_DcuB" amino acids 5 to 365 (361 residues), 490.9 bits, see alignment E=3.3e-151 PF03600: CitMHS" amino acids 32 to 344 (313 residues), 33.9 bits, see alignment E=2.9e-12 PF03606: DcuC" amino acids 48 to 406 (359 residues), 34 bits, see alignment E=1.9e-12

Best Hits

Swiss-Prot: 100% identical to DCUA_ECOLI: Anaerobic C4-dicarboxylate transporter DcuA (dcuA) from Escherichia coli (strain K12)

KEGG orthology group: K07791, anaerobic C4-dicarboxylate transporter DcuA (inferred from 100% identity to eco:b4138)

MetaCyc: 100% identical to C4-dicarboxylate transporter DcuA (Escherichia coli K-12 substr. MG1655)
TRANS-RXN-106; TRANS-RXN-106A; TRANS-RXN-106B; TRANS-RXN-299; TRANS-RXN-379

Predicted SEED Role

"C4-dicarboxylate transporter DcuA"

MetaCyc Pathways

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (433 amino acids)

>HEPCGN_10665 anaerobic C4-dicarboxylate transporter DcuA (Escherichia coli ECOR38)
MLVVELIIVLLAIFLGARLGGIGIGFAGGLGVLVLAAIGVKPGNIPFDVISIIMAVIAAI
SAMQVAGGLDYLVHQTEKLLRRNPKYITILAPIVTYFLTIFAGTGNISLATLPVIAEVAK
EQGVKPCRPLSTAVVSAQIAITASPISAAVVYMSSVMEGHGISYLHLLSVVIPSTLLAVL
VMSFLVTMLFNSKLSDDPIYRKRLEEGLVELRGEKQIEIKSGAKTSVWLFLLGVVGVVIY
AIINSPSMGLVEKPLMNTTNAILIIMLSVATLTTVICKVDTDNILNSSTFKAGMSACICI
LGVAWLGDTFVSNNIDWIKDTAGEVIQGHPWLLAVIFFFASALLYSQAATAKALMPMALA
LNVSPLTAVASFAAVSGLFILPTYPTLVAAVQMDDTGTTRIGKFVFNHPFFIPGTLGVAL
AVCFGFVLGSFML