Protein Info for HEPCGN_09745 in Escherichia coli ECOR38

Name: betT
Annotation: choline transporter

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 665 transmembrane" amino acids 18 to 37 (20 residues), see Phobius details amino acids 57 to 77 (21 residues), see Phobius details amino acids 97 to 117 (21 residues), see Phobius details amino acids 148 to 168 (21 residues), see Phobius details amino acids 192 to 215 (24 residues), see Phobius details amino acids 235 to 255 (21 residues), see Phobius details amino acids 267 to 287 (21 residues), see Phobius details amino acids 324 to 342 (19 residues), see Phobius details amino acids 354 to 380 (27 residues), see Phobius details amino acids 408 to 429 (22 residues), see Phobius details amino acids 453 to 472 (20 residues), see Phobius details amino acids 479 to 498 (20 residues), see Phobius details PF02028: BCCT" amino acids 19 to 504 (486 residues), 656.5 bits, see alignment E=1.1e-201 TIGR00842: transporter, betaine/carnitine/choline transporter (BCCT) family" amino acids 57 to 504 (448 residues), 540.9 bits, see alignment E=1.1e-166

Best Hits

Swiss-Prot: 55% identical to GBTR_ACIAD: Glycine betaine transporter (ACIAD3460) from Acinetobacter baylyi (strain ATCC 33305 / BD413 / ADP1)

KEGG orthology group: K02168, high-affinity choline transport protein (inferred from 100% identity to eck:EC55989_4947)

Predicted SEED Role

"Secondary glycine betaine transporter BetU"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (665 amino acids)

>HEPCGN_09745 choline transporter (Escherichia coli ECOR38)
MSENDTIPKKSTSQINKAVFFTSALLIFLLVAFAAVFPDVADKNFKLLQQQIFTNASWFY
ILAVALILLSVTFLGLSRYGDIKLGPDHAQPDFSYHSWFAMLFSAGMGIGLMFFGVAEPV
MHYLSPPVGTPETVAAAKEAMRLTFFHWGLHAWAIYAIVALILAFFSYRHGLPLTLRSAL
YPIIGDRIYGPVGHAVDIFAVIGTVFGVATSLGYGVLQVNAGLNHLFGVPINETVQVILI
VVITGLATISVVSGLDKGIRILSELNLGLALLLLALVLCLGPTVLLLKSFVENTGGYLSE
LVSKTFNLYAYEPKSSNWLGGWTLLYWGWWLSWSPFVGMFIARVSRGRTIREFVTGVLFV
PAGFTLMWMTVFGNSAIYLIMNQGATDLANTVQQDVALALFNFLEHFPFSSVLSFIAMAM
VIVFFVTSADSGAMVVDTLASGGVANTPVWQRIFWASLMGIVAIALLLAGGLSALQTVTI
ASALPFSVILLISIYGLLKALRRDLTKRESLSMATIAPTAARNPIPWQRRLRNIAYLPKR
SLVKRFMDDVIQPAMTLVQEELNKQGTISHISDAVDDRIRLEVDLGNELNFIYEVRLRGY
ISPTFALAAMDNDEQQTEQHRYYRAEVYLKEGGQNYDVMGWNQEQLINDILDQYEKHLHF
LHLVR