Protein Info for HEPCGN_08500 in Escherichia coli ECOR38

Name: ampE
Annotation: beta-lactamase regulator AmpE

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 284 signal peptide" amino acids 1 to 17 (17 residues), see Phobius details transmembrane" amino acids 40 to 58 (19 residues), see Phobius details amino acids 65 to 85 (21 residues), see Phobius details amino acids 144 to 168 (25 residues), see Phobius details amino acids 266 to 283 (18 residues), see Phobius details PF17113: AmpE" amino acids 1 to 284 (284 residues), 527.3 bits, see alignment E=4.8e-163

Best Hits

Swiss-Prot: 98% identical to AMPE_SHIFL: Protein AmpE (ampE) from Shigella flexneri

KEGG orthology group: K03807, AmpE protein (inferred from 100% identity to ect:ECIAI39_0111)

Predicted SEED Role

"AmpE protein"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (284 amino acids)

>HEPCGN_08500 beta-lactamase regulator AmpE (Escherichia coli ECOR38)
MTLFTTLLVLIFERLFKLGEHWQLDHRLEAFFRRVKHFSLGRTLGMTIIAMGATFLLLRA
LHGLLFNVPTLVVWLLIGLLCIGAGKVRLHYHAYLTAASRNDSHARSTMAGELTMIHGVP
AGCDEREFLRELQNALLWINFRFYLAPLFWLIVGGIWGPVTLMGYAFLRAWQYWLARYQT
PHHRLQSGIDAVLHVLDWVPVRLAGVVYALIGHGEKALPAWFASLGDFHTSQYQVLTRLA
QFSLAREPHVDKVETPKAAVSMAKKTSFVVVVVIALLTIYGALV