Protein Info for HEPCGN_06805 in Escherichia coli ECOR38

Name: mscK
Annotation: mechanosensitive channel MscK

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1000 1120 signal peptide" amino acids 1 to 36 (36 residues), see Phobius details transmembrane" amino acids 499 to 522 (24 residues), see Phobius details amino acids 557 to 579 (23 residues), see Phobius details amino acids 587 to 606 (20 residues), see Phobius details amino acids 630 to 647 (18 residues), see Phobius details amino acids 658 to 679 (22 residues), see Phobius details amino acids 691 to 716 (26 residues), see Phobius details amino acids 728 to 749 (22 residues), see Phobius details amino acids 795 to 820 (26 residues), see Phobius details amino acids 840 to 860 (21 residues), see Phobius details amino acids 881 to 903 (23 residues), see Phobius details amino acids 914 to 941 (28 residues), see Phobius details PF12795: MscS_porin" amino acids 50 to 289 (240 residues), 212.5 bits, see alignment E=1.9e-66 PF12794: MscS_TM" amino acids 509 to 826 (318 residues), 332 bits, see alignment E=9e-103 PF21088: MS_channel_1st" amino acids 887 to 928 (42 residues), 43.4 bits, see alignment (E = 6.4e-15) PF00924: MS_channel_2nd" amino acids 930 to 995 (66 residues), 85.6 bits, see alignment 5e-28 PF21082: MS_channel_3rd" amino acids 1004 to 1086 (83 residues), 75.9 bits, see alignment 6.8e-25

Best Hits

Swiss-Prot: 100% identical to MSCK_ECOLI: Mechanosensitive channel MscK (mscK) from Escherichia coli (strain K12)

KEGG orthology group: K05802, potassium efflux system protein KefA (inferred from 100% identity to ect:ECIAI39_0206)

MetaCyc: 100% identical to potassium dependent, small conductance mechanosensitive channel (Escherichia coli K-12 substr. MG1655)
TRANS-RXN-86

Predicted SEED Role

No annotation

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (1120 amino acids)

>HEPCGN_06805 mechanosensitive channel MscK (Escherichia coli ECOR38)
MTMFQYYKRSRHFVFSAFIAFVFVLLCQNTAFARASSNGDLPTKADLQAQLDSLNKQKDL
SAQDKLVQQDLTDTLATLDKIDRVKEETVQLRQKVAEAPEKMRQATAALTALSDVDNDEE
TRKILSTLSLRQLETRVAQALDDLQNAQNDLASYNSQLVSLQTQPERVQNAMYNASQQLQ
QIRSRLDGTDVGETALRPSQKVLMQAQQALLNAEIDQQRKSLEGNTVLQDTLQKQRDYVT
ANSARLEHQLQLLQEAVNSKRLTLTEKTAQEAVSPDEAARIQANPLVKQELEINQQLSQR
LITATENGNQLMQQNIKVKNWLERALQSERNIKEQIAVLKGSLLLSRILYQQQQTLPSAD
ELENMTNRIADLRLEQFEVNQQRDALFQSDAFVNKLEEGHTNEVNSEVHDALLQVVDMRR
ELLDQLNKQLGNQLMMAINLQINQQQLMSVSKNLKSILTQQIFWVNSNRPMDWDWIKAFP
QSLKDEFKSMKITVNWEKAWPAVFIAFLAGLPLLLIAGLIHWRLGWLKAYQQKLASAVGS
LRNDSQLNTPKAILIDLIRALPVCLIILAVGLILLTMQLNISELLWSFSKKLAIFWLVFG
LCWKVLEKNGVAVRHFGMPEQQTSHWRRQIVRISLALLPIHFWSVVAELSPLHLMDDVLG
QAMIFFNLLLIAFLVWPMCRESWRDKESHTMRLVTITVLSIIPIALMVLTATGYFYTTLR
LSGRWIETVYLVIIWNLLYQTVLRGLSVAARRIAWRRALARRQNLVKEGAEGAEPPEEPT
IALEQVNQQTLRITMLLMFALFGVMFWAIWSDLITVFSYLDSITLWHYNGTEAGAAVVKN
VTMGSLLFAIIASMVAWALIRNLPGLLEVLVLSRLNMRQGASYAITTILNYIIIAVGAMT
VFGSLGVSWDKLQWLAAALSVGLGFGLQEIFGNFVSGLIILFERPVRIGDTVTIGSFSGT
VSKIRIRATTITDFDRKEVIIPNKAFVTERLINWSLTDTTTRLVIRLGVAYGSDLEKVRK
VLLKAATEHPRVMHEPMPEVFFTAFGASTLDHELRLYVRELRDRSRTVDELNRTIDQLCR
ENDINIAFNQLEVHLHNEKGDEVTEVKRDYKGDDPTPAVG